Identification, Biocontrol and Plant Growth Promotion Potential of Endophytic Streptomyces sp. a13.

Medicinal plants often harbour various endophytic actinomycetia, which are well known for their potent antimicrobial properties and plant growth-promoting traits. In this study, we isolated an endophytic actinomycetia, A13, from the leaves of tea clone P312 from the MEG Tea Estate, Meghalaya, India. The isolate A13 was identified as Streptomyces sp.

Breaking boundaries in diabetic nephropathy treatment: design and synthesis of novel steroidal SGLT2 inhibitors.

The activity of sodium glucose co-transporter 2 (SGLT2) has always been an important parameter influencing chronic kidney disease in type-2 diabetic patients. Herein, we have meticulously designed, synthesized, and evaluated several novel steroidal pyrimidine molecules that possess the capability to successfully bind to the SGLT2 protein and inhibit its activity, thereby remedying kidney-related ailments in diabetic patients. The lead steroidal pyrimidine compounds were selected after virtually screening from a library of probable -heterocyclic steroidal scaffolds.

Microplastics abundance and potential ecological risk assessment in sediment, water and fish of Deepor Beel-a Ramsar Wetland of the Brahmaputra plain, India.

Microplastics (MPs) are increasingly recognized as environmental contaminants with complex impacts on fish and other aquatic organisms. This study determined the microplastics abundance and the induced-ecological risks of microplastics in water, sediment, and commonly harvested fishes of a Ramsar site, Deepor Beel of Assam, India. Six samples of water and sediment were collected with nine individuals of two commonly harvested fish species Puntius sophore (Pool Barb) and Gudusia chapra (Indian River Shad).

Therapeutic Potential of Quercetin in Diabetic Neuropathy and Retinopathy: Exploring Molecular Mechanisms.

Diabetes mellitus poses a significant health challenge globally, often leading to debilitating complications, such as neuropathy and retinopathy. Quercetin, a flavonoid prevalent in fruits and vegetables, has demonstrated potential therapeutic effects in these conditions due to its antioxidant, anti-inflammatory, and neuroprotective properties. This review summarizes and provides a comprehensive understanding of the molecular mechanisms underlying the efficacy of quercetin in ameliorating diabetic neuropathy and retinopathy.

Evaluating the Potential of Bacillus Isolates for Chlorpyrifos Degradation and Their Role in Tea Growth Promotion and Suppression of Pathogens.

Pesticides employed for controlling domestic and agricultural pests are among the most dangerous environmental contaminants. Nevertheless, negligent usage and a lack of technical expertise have led to the contamination and pollution of various ecological niches. The extensive utilization of the organophosphate chlorpyrifos (CPs) for insect infestation control, coupled with its detrimental effects and persistence in the ecosystem, has led to calls for its removal from contaminated sites.

Synthesis, characterization, and cancer cell-selective cytotoxicity of mixed-ligand cobalt(III) complexes of 8-hydroxyquinolines and phenanthroline bases.

Transition metal complexes exhibiting selective toxicity towards a broad range of cancer types are highly desirable as potential anticancer agents. Herein, we report the synthesis, characterization, and cytotoxicity studies of six new mixed-ligand cobalt(III) complexes of general formula [Co(B)(L)](ClO) (1-6), where B is a N,N-donor phenanthroline base, namely, 1,10-phenanthroline (phen in 1, 2), dipyrido[3,2-:2',3'-]quinoxaline (dpq in 3, 4), and dipyrido[3,2-:2',3'-]phenazine (dppz in 5, 6), and L is the monoanion of 8-hydroxyquinoline (HQ in 1, 3, 5) and 5-chloro-7-iodo-8-hydroxyquinoline (CQ in 2, 4, 6). The X-ray single crystal structures of complexes 1 and 2 as PF salts revealed a distorted octahedral CoNO coordination environment.

Chemical and biochemical characterization of : genoprotective potential and inhibitory mechanism of its phytochemicals against α-amylase and α-glucosidase.

also known as water spinach, is an aquatic non-conventional leafy vegetable and is considered a healthy and seasonal delicacy in ethnic food culture. The study revealed the presence of rich chemical and biochemical composition in and antioxidant activities. Moreover, the plant extracts demonstrated significant DNA damage prevention activity against UV/HO-induced oxidative damage.

Potentiality of Actinomycetia Prevalent in Selected Forest Ecosystems in Assam, India to Combat Multi-Drug-Resistant Microbial Pathogens.

Actinomycetia are known for their ability to produce a wide range of bioactive secondary metabolites having significant therapeutic importance. This study aimed to explore the potential of actinomycetia as a source of bioactive compounds with antimicrobial properties against multi-drug-resistant (MDR) clinical pathogens. A total of 65 actinomycetia were isolated from two unexplored forest ecosystems, namely the Pobitora Wildlife Sanctuary (PWS) and the Deepor Beel Wildlife Sanctuary (DBWS), located in the Indo-Burma mega-biodiversity hotspots of northeast India, out of which 19 isolates exhibited significant antimicrobial activity.

Dedifferentiated endometrial carcinoma arising from serous carcinoma: Diagnostic challenges and recommendations.

•Dedifferentiated endometrial carcinoma arising from serous carcinoma (null-type P53).•Differential diagnosis including carcinosarcoma, FIGO grade 3 endometrioid carcinoma.•Also need to rule out SMARCA4-deficient uterine sarcoma and other sarcomas.

Understanding the factors leading to high prevalence of teenage pregnancies in the four aspirational Districts of Assam, Namely Goalpara, Barpeta, Dhubri, and darrang.

Background: The prevalence of teenage pregnancy in Assam is higher than the national average as per both NHFS-4 and NHFS-5. Four districts in Assam, falling under the NITI-Aayog Aspiration Districts Transformation program of 2018, namely, Goalpara, Barpeta, Darrang, and Dhubri, have a prevalence of teenage pregnancy at levels higher than the state's average (12% as per NHFS-5). Teenage pregnancy affects several health and nutritional indicators.

Advances in enzymatic conversion of biomass derived furfural and 5-hydroxymethylfurfural to value-added chemicals and solvents.

The progress of versatile chemicals and bio-based fuels using renewable biomass has gained ample importance. Furfural and 5-hydroxymethylfurfural are biomass-derived compounds that serve as the cornerstone for high-value chemicals and have a myriad of industrial applications. Despite the significant research into several chemical processes for furanic platform chemicals conversion, the harsh reaction conditions and toxic by-products render their biological conversion an ideal alternative strategy.

Snake venom nerve growth factor-inspired designing of novel peptide therapeutics for the prevention of paraquat-induced apoptosis, neurodegeneration, and alteration of metabolic pathway genes in the rat pheochromocytoma PC-12 cell.

Neurodegenerative disorders (ND), associated with the progressive loss of neurons, oxidative stress-mediated production of reactive oxygen species (ROS), and mitochondrial dysfunction, can be treated with synthetic peptides possessing innate neurotrophic effects and neuroprotective activity. Computational analysis of two small synthetic peptides (trideca-neuropeptide, TNP; heptadeca-neuropeptide, HNP) developed from the nerve growth factors from snake venoms predicted their significant interaction with the human TrkA receptor (TrkA). In silico results were validated by an in vitro binding study of the FITC-conjugated custom peptides to rat pheochromocytoma PC-12 cell TrkA receptors.

Characterization and selection of endophytic actinobacteria for growth and disease management of Tea ( L.).

Endophytic microbes are vital for nutrient solubilization and uptake, growth, and survival of plants. Here, 88 endophytic actinobacteria (EnA) associated with five tea clones were isolated, assessed for their diversity, plant growth promoting (PGP), and biocontrol traits, and then used as an inoculant for PGP and disease control in host and non-host plants. Polyphasic methods, including phenotypic and genotypic characteristics led to their identification as , and Out of 88 isolates, 35 (39.

Taxifolin-3-O-glucoside from Osbeckia nepalensis Hook. mediates antihyperglycemic activity in CC1 hepatocytes and in diabetic Wistar rats via regulating AMPK/G6Pase/PEPCK signaling axis.

Ethnopharmacological Relevance: Osbeckia nepalensis Hook. f. is an ICMR documented plant well known for its antidiabetic uses among the folk people of Northeast Region of India.

Kaempferol 3-O-rutinoside from Antidesma acidum Retz. Stimulates glucose uptake through SIRT1 induction followed by GLUT4 translocation in skeletal muscle L6 cells.

Ethnopharmacological Relevance: Antidesma acidum Retz, a perennial herb is known for its anti-diabetic potential among the traditional health care providers of the tribal communities of Manipur, India. Scientific validation of the ancient knowledge on traditional use of this plant with the help of modern tools and techniques can promote further research and its use in health care.

Aim Of The Study: Type 2 Diabetes (T2D) is a complex metabolic disorder and linked with hyperglycemia occurring from insufficiency in insulin secretion, action, or both.

Evaluating the potential of engineered Trichoderma atroviride and its laccase-mediated system for the efficient bioconversion of 5-hydroxymethylfufural.

5-Hydroxymethylfurfural (HMF) is a fermentation inhibitor which is formed during acid-based thermochemical pre-treatment of biomass. The present study involves two approaches for HMF conversion; the first includes screening and identification of fungal strains which produce oxidoreductases for HMF bioconversion, and thereafter evaluating their roles in HMF conversion. Out of the ten fungal strains screened, genetically engineered Trichoderma atroviride (Lac) showed maximum HMF bioconversion and the activities of ligninolytic enzymes produced were noted.

Utilization of surface-active compounds derived from biosolids to remediate polycyclic aromatic hydrocarbons contaminated sediment soil.

In the present study, surface-active compounds (SAC) were extracted from biosolids using an alkaline treatment process. They were tested for their remediation efficiency of crude oil-contaminated sediment soil and was compared with Triton x-100. The SAC exhibited a similar soil washing efficiency to that of the commercial Triton x-100, and under the optimized soil washing parameters, SAC exhibited a maximum of 91% total polycyclic aromatic hydrocarbons removal.

Association of histo-blood group antigens and predisposition to gastrointestinal diseases.

Infectious gastroenteritis is a common illness afflicting people worldwide. The two most common etiological agents of viral gastroenteritis, rotavirus and norovirus are known to recognize histo-blood group antigens (HBGAs) as attachment receptors. ABO, Lewis, and secretor HBGAs are distributed abundantly on mucosal epithelia, red blood cell membranes, and also secreted in biological fluids, such as saliva, intestinal content, milk, and blood.

Laccase production by Pleurotus ostreatus using cassava waste and its application in remediation of phenolic and polycyclic aromatic hydrocarbon-contaminated lignocellulosic biorefinery wastewater.

The treatment of contaminants from lignocellulosic biorefinery effluent has recently been identified as a unique challenge. This study focuses on removing phenolic contaminants and polycyclic aromatic hydrocarbons (PAHs) from lignocellulosic biorefinery wastewater (BRW) applying a laccase-assisted approach. Cassava waste was used as a substrate to produce the maximum yield of laccase enzyme (3.

Performance study on adsorptive removal of acetaminophen from wastewater using silica microspheres: Kinetic and isotherm studies.

Owing to the global industrialization, a new generation of pharmaceutical pollutants with high toxicity and persistency have been detected. In the present study, silica microspheres, a promising adsorbent has been employed to investigate the extent of removal of prevalent therapeutic acetaminophen, an emerging micropollutant, from wastewater in isolated batch experiments. The BET surface area of the adsorbent was 105.

Mycoremediation of lignocellulosic biorefinery sludge: A reinvigorating approach for organic contaminants remediation with simultaneous production of lignocellulolytic enzyme cocktail.

This research work aims to valorize lignocellulosic biorefinery sludge with genetically engineered Trichoderma atroviride for simultaneous removal of organic contaminants, fermentation inhibitors, and lignocellulolytic enzyme cocktail production. Upon analysis, three phenolic compounds (42.6 ± 3.

Surfactant-aided mycoremediation of soil contaminated with polycyclic aromatic hydrocarbons.

Remediation of persistent polycyclic aromatic hydrocarbons (PAHs) contaminated soil has become a major challenge in recent years. Further, conventional application of bioaugmentation strategies for PAHs remediation require continuous supply of microbial specific nutrients, which makes these processes less feasible. Hence, the present study focused on PAHs remediation using surfactants along with wood assisted fungal system in a microcosm set up.

Insolubilization of Tramates versicolor laccase as cross-linked enzyme aggregates for the remediation of trace organic contaminants from municipal wastewater.

The novelty of this study deals with the biocatalytic treatment of trace organic contaminants (TrOCs) from municipal wastewater by insolubilized laccase. Laccase from Trametes versicolor was aggregated by three-phase partitioning technique followed by cross-linking with glutaraldehyde to produce insolubilized laccase as cross-linked enzyme aggregates (CLEAs). The optimal conditions for CLEAs preparation include ammonium sulphate concentration of 83% (w/v), crude to t-butanol ratio of 1.