Validating phosphoethanolamine modification as a potential spectral marker of colistin resistance.

The antibiotic colistin is regarded as the final line of defense for treating infections caused by Gram-negative bacteria. The combination of Raman spectroscopy (RS) with diverse machine learning methods has helped unravel the complexity of various microbiology problems. This approach offers a culture-free, rapid, and objective tool for identifying antimicrobial resistance (AMR).

Bimetallic NiCo Nanoparticles Embedded in Organic Group Functionalized Mesoporous Silica for Efficient Hydrogen Production from Ammonia Borane Hydrolysis.

In this study, bimetallic NiCo nanoparticles (NPs) were encapsulated within the mesopores of carboxylic acid functionalized mesoporous silica (CMS) through the chemical reduction approach. Both NaBH and NHBH were used as reducing agents to reduce the metal ions simultaneously. The resulting composite was used as a catalyst for hydrolysis of ammonia borane (NHBH, AB) to produce H.

A Network Meta-Analysis of Randomized Controlled Trials on the Comparative Efficacy of Stem Cells Therapy for Diabetic Foot Ulcer Healing.

Stem cell therapy in diabetic foot ulcer has emerged as a promising treatment option to promote ulcer healing. This network meta-analysis was undertaken to evaluate how they compete with each other and their ranking with respect to chances of ulcer healing. A systematic search strategy to retrieve data from five databases, were used to identify potential studies.

A brief review on the lessons learned from COVID-19 on drug discovery and research.

COVID-19 pandemic has taught many lessons regarding drug discovery and development. This review covers these aspects of drug discovery and research for COVID-19 which might be used as a tool for future. It summarizes the positives such as progresses in antiviral drug discovery, drug repurposing, adaptations of clinical trial and its regulations, as well as the negative points such as the need to develop more collaboration among stakeholders and future directions.

Prosthesis for Unilateral Isolated Proximal Focal Femoral Deficiency: A Case Report and Review of the Literature.

A 14-month-old female child was brought to us by her parents with the complaint of progressive shortening of her right lower limb since birth. Born to non-consanguineous parents from a poor socioeconomic background, her birth and antenatal history were uneventful. Physical examination revealed no facial dysmorphism; however, her right thigh was short and bulky, and there were restrictions in hip, knee, and ankle movements.

Validating the utility of heavy water (Deuterium Oxide) as a potential Raman spectroscopic probe for identification of antibiotic resistance.

The impact of microbial infections is increasing over time, and it is one of the major reasons for death in both developed and developing countries. colistin is considered as the antibiotic of last choice for infections brought by major multidrug-resistant (MDR), gram-negative bacteria such as Enterobacter species, Acinetobacter species, and Pseudomonas aeruginosa. Existing approaches to diagnose these resistant species are relatively slow and take up to 2 to 3 days.

Dynamics of caste and early childbearing in India: a perspective of three decades.

Background: Early childbearing disrupts girls' otherwise healthy growth into adulthood and adversely affects their education, livelihood, and health. Individual, sociocultural, economic, environmental, and health service-related factors contribute to childbearing among young females. In India, caste affects health outcomes despite several affirmative policies aimed at improving the health and welfare of the backward castes/tribes.

Gallic Acid Derived 1, 2-Diarylindole as a Potential Antifungal Agent against Candida Strain.

Background: In recent decades, Candida albicans has become a serious issue for public health. The worldwide rapid rise in drug resistance to conventional therapies is the main contributing reason. Moreover, because of their potent activity at low concentrations and apparent lack of toxicity, compounds originating from plants are used in therapeutic treatments because of their potent activity at low concentrations and apparent lack of toxicity.

Development and Performance Analysis of an Automatic Core Cutter for Elephant Apple ( L.) Processing.

Elephant apple, a fruit with numerous bioactive compounds, is rich in therapeutic qualities. However, its use in processed products is limited due to insufficient postharvest processing methods. To address this issue, an automatic core cutter (ACC) was developed to handle the hard nature of the fruit while cutting.

Effectiveness of Stem Cell Therapy for Diabetic Foot Ulcers: A Systematic Review and GRADE Compliant Bootstrapped Meta-Analysis of Randomized Clinical Trials.

Diabetic foot (DF) represents a severe complication of diabetes mellitus, imposing substantial psychological and economic burdens on affected individuals. This investigation sought to assess the therapeutic efficacy of stem cell interventions in the management of DF complications. A comprehensive systematic search across PubMed, Embase, CINAHL, Scopus, and the Cochrane library databases was conducted to identify pertinent studies for meta-analysis.

Impact of alkaline earth metal doping on the structural, electronic, and optical properties of all inorganic lead-free CsSnX(X = I, Br) perovskites: a first-principles study.

Recently, researchers have focused on developing more stable, Pb-free perovskites with improved processing efficiency and notable light harvesting ability. In this regard, Sn-based (Sn-b) perovskites have gained considerable interest in developing eco-friendly perovskite solar cells (PSCs). However, the oxidation of Snto Sndeteriorates the performance of Sn-b PSCs.

Serum Micronutrients and Antioxidant Levels in Children With Transfusion-Dependent Thalassemia.

Objectives: To estimate serum zinc, copper, magnesium and antioxidant levels in children with transfusion-dependent thalassemia (TDT).

Methods: Cross-sectional study, enrolling children with TDT aged 3-14 years and age-matched healthy children without thalassemia. Serum zinc, copper, magnesium and total antioxidant capacity were estimated by direct colorimetric method and ELISA, respectively.

Experimental safety testing confirms that the NSAID nimesulide is toxic to Gyps vultures in India.

Population declines of Gyps vultures throughout South Asia were caused by unintentional poisoning by the NSAID diclofenac, which was subsequently banned. However, other vulture-toxic NSAIDs are available, including nimesulide, which, in experiments carried out in South Africa, was shown to be toxic to Gyps vultures. We report on safety-testing of nimesulide carried out on Himalayan Griffons G.

Correction to "Green-Based Approach to Synthesize Silver Nanoparticles Using the Fungal Endophyte and Their Antimicrobial, Antioxidant, and Anticancer Potential".

[This corrects the article DOI: 10.1021/acsomega.2c05605.

Bioactive Compounds and Health-Promoting Properties of Elephant Apple ( L.): A Comprehensive Review.

Elephant apple ( L.) grows wild in Southeast Asia's forests, including in China, India, Nepal, Bangladesh, and Sri Lanka. Elephant apples are considered essential fruit crops because of their high nutritional value, which includes high levels of vitamin C, carbohydrates, fats, fibre, protein, minerals, and fatty acids.

Gene expression and molecular characterization of recombinant subtilisin from Bacillus subtilis with antibacterial, antioxidant and anticancer properties.

This study investigated the multifunctional attributes such as, antibacterial, antioxidant and anticancer potential of recombinant subtilisin. A codon-optimized subtilisin gene was synthesized from Bacillus subtilis and was successfully transformed into E. coli DH5α cells which was further induced for high level expression in E.

RIG-I expression pattern and cytokine profile in indigenous ducks infected with duck plague virus.

The present study was undertaken to elucidate mRNA expression pattern of RIG-I and serum cytokines profile alterations in indigenous ducks of Assam, India viz. Pati, Nageswari and Cinahanh in response to natural infections of duck plague virus. Field outbreaks of duck plague virus were attended during the study period for collection of tissue and blood samples.

Characterization of new natural cellulosic fiber from (Jati Bet) cane as a potential reinforcement for polymer composites.

This study investigates the physical, structural, chemical, thermal, mechanical, and morphological properties of the fibers of canes and compares the findings with various lignocellulosic fibers to find the place of these fibers as reinforcements for polymer composites. Chemical analysis confirms the presence of 37.43 ± 1.

Sexual Dimorphism in Teeth Dimension and Arch Perimeter of Individuals of Four Ethnic Groups of Northeastern India.

Objectives There is a disparity between males and females when it comes to size and appearance. In forensic and anthropological investigations, it is crucial to identify an unknown individual's gender, and it is possible to discern individual differences based on differences in dental features among populations. For identifying individuals, tooth dimensions are an effective, simple, and low-cost means of determining sex.

Why do women abort their pregnancies? Evidence from the National Family Health Survey (2019-21) of India.

Induced abortion is closely associated with maternal morbidity, mortality, and reproductive rights of women and thus continues to draw research interest. This study assesses the reasons for abortion and their predictors using India's National Family Health Survey-5 (2019-21) data. The sample of women aged 15-49 who had terminated their last pregnancy by induced abortion in the five years preceding the survey (n=5835) was considered for analysis.

Dyslipidemia and atherogenic indexes in children with transfusion-dependent thalassemia.

Objective: This study endeavored to assess the lipid profile and atherogenic lipid indexes in children with transfusion-dependent thalassemia (TDT) and to compare them with matched healthy children.

Method: The study group consisted of a total of 72 TDT patients aged 3 to14 years, while the control group had 83 age- and sex-matched healthy children. The fasting lipid profile and lipid indexes were estimated and the atherogenic index of plasma (AIP), Castelli's risk indexes I and II, atherogenic coefficient were calculated and compared between the two groups.