Tunable Exciton-Driven Photoelasticity in 2D Material Acoustic Cavities.

While coupling between optical, electronic, and mechanical domains is paramount for high-frequency acoustic devices, materials that offer tunability in the degree of such coupling can be crucially enabling in expanding device functionality. Here, we show that the interaction of photons with coherent acoustic phonons confined in 2D layered semiconducting cavities can be controlled through either modifying the material state via a thermally induced electronic bandgap shift (EBS) or altering the polarization state of the incoming photons when optical birefringence is present in the cavity. We demonstrate temperature-driven EBS as an effective tool to engineer the WSe cavity readout as it allows one to sweep the excitonic energy relative to a chosen probe wavelength.

A New Approach to Synthesizing Carbon-11-PBR28 and its Clinical Validation in ALS Patients.

Background: Many studies have reported Translocator Protein (TSPO) overexpression in many neurological disorders. Carbon-11[11C]PBR28 is a widely used TSPO Positron Emission Tomography (PET) radiopharmaceutical. We have compared HPLC-based purification with cartridge-based purification and performed PET-MR imaging in ALS patients.

Exploring the role of altered oxi-inflammasome activity in the immunobiology of inflammatory neuropathies.

Objectives: Inflammasome plays a significant role in inflammatory responses. The role of inflammasome and its interactions with oxidative stress markers has not been examined in inflammatory neuropathies like Guillain-Barré syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). This study aims to explore the roles of inflammasome and oxidative stress pathways in inflammatory neuropathies.

Exploring the role of the IL-12/IFN-γ immune axis in subacute sclerosing panencephalitis.

Background: Subacute sclerosing panencephalitis (SSPE) is a rare but fatal neurological syndrome resulting from persistent measles virus infection in the central nervous system. Despite the availability of a measles vaccine, SSPE continues to pose a significant health burden, and immunogenetic risk factors remain unclear. We aimed to study the role of the interleukin 12 (IL-12)/interferon-gamma (IFN-γ) axis, known for it's significance in antiviral defense, in the development of SSPE.

A critical review on the organo-metal(loid)s pollution in the environment: Distribution, remediation and risk assessment.

Toxic metal(loid)s, e.g., mercury, arsenic, lead, and cadmium are known for several environmental disturbances creating toxicity to humans if accumulated in high quantities.

Microplastics in the soil-water-food nexus: Inclusive insight into global research findings.

Nuisance imposed by biotic and abiotic stressors on diverse agroecosystems remains an area of focus for the scientific fraternity. However, emerging contaminants such as microplastics (MP) have imposed additional dimension (alone or in combinations with other stressors) in agroecosystems and keep escalating the challenges to achieve sustainability. MP are recognized as persistent anthropogenic contaminants, fetch global attention due to their unique chemical features that keeps themselves unresponsive to the decaying process.

Prevalence of Extended-Spectrum β-Lactamases (ESBLs) Producing spp. Isolated from (Lamark, 1819) of Sewage-Fed Wetland: A Phenotypic and Genotypic Approach.

The global rise of zoonotic bacteria resistant to multiple antimicrobial classes and the growing occurrence of infections caused by spp. resistant to β-lactam antibiotics pose a severe threat to animal and human health. However, the contribution of natural environments, particularly aquatic ecosystems, as ideal settings for the development and spread of antimicrobial resistance (AMR) is a key concern.

Association of Insulin-like Growth Factor-1 and Neurofilament Light Chain in Patients with Progressive Supranuclear Palsy.

Background: Progressive supranuclear palsy (PSP) is the most common primary tauopathy. The definite diagnosis of PSP is established by histopathologic changes in the brain. There are no reliable blood-based biomarkers to aid the diagnosis of this fatal disease at an early stage.

Synergistic effects of immune checkpoints and checkpoint inhibitors in inflammatory neuropathies: Implications and mechanisms.

Immune checkpoint molecules play pivotal roles in the regulation of immune homeostasis. Disruption of the immune checkpoints causes autoimmune/inflammatory as well as malignant disorders. Over the past few years, the immune checkpoint molecules with inhibitory function emerged as potential therapeutic targets in oncological conditions.

Auxiliary superfield method for statistical predictions of complex, structural acoustics systems: Saddle point approximation for the mean field.

The auxiliary superfield approach is proposed as a method to obtain statistical predictions of the acoustic response of complex elastic structures. The potential advantage of the method is the full retention of interference and resonance effects associated with the degrees of freedom being averaged over. It is not known whether this approach leads to tractable problems for structural acoustics systems, however.

Genetic and Epigenetic Constructs of Progressive Supranuclear Palsy.

Background: Progressive supranuclear palsy (PSP) is a rapidly progressive primary tauopathy characterized by vertical gaze palsy, postural instability, and mild dementia. PSP shows high clinical and pathologic heterogeneity. Although a few risk factors exist, such as advanced age and environmental toxins, the precise etiology remains largely elusive.

Effect of treatment regimens in severe COVID pneumonia at an Indian tertiary care hospital: An observational, real-world study.

Background: Corticosteroids have attracted attention as a treatment option for severe Coronavirus disease (COVID-19). However, published data on steroid therapy is debatable, and real-world data is lacking. This study evaluated the effect of treatment regimens, especially Pulse steroid therapy (Injection Methyl Prednisolone 250 mg iv once a day for three days) in severe-COVID-19 pneumonia at an Indian tertiary care hospital.

Role of altered IL-33/ST2 immune axis in the immunobiology of Guillain-Barré syndrome.

Background: The IL-33/ST2 immune axis plays crucial roles in infection and immunity. A dysregulated IL-33/ST2 axis can induce autoimmune reaction and inflammatory responses. Guillain-Barré syndrome (GBS) is an acute peripheral neuropathy, mostly caused by post-infection autoimmunity.

Seroprevalence of bluetongue and presence of viral antigen and type-specific neutralizing antibodies in goats in Tripura, a state at Indo-Bangladesh border of northeastern India.

Bluetongue (BT) is a notifiable multiple species transboundary viral disease of domestic and wild ruminants. Though the disease is enzootic in India, little is known of the disease burden and prevalent serotypes in Tripura, a hilly state of northeastern India sharing a vast porous border with Bangladesh. A surveillance study was conducted to understand the disease burden in goats in Tripura.

Compact directional acoustic sensor using a multi-fiber optical probe.

A compact directional acoustic sensor is described which uses a two-fiber optical probe, a light emitting diode (LED), a photo-diode detector, and a slender cylindrical cantilever to the end of which is attached an optical reflector. Acoustically induced transverse displacement of the cantilever tip modulates the light reflected by it into the collection fiber, which conveys the light to a photo-detector. Directional sensitivity is achieved through the dependence of the collected light on the cosine of the angle between a line through the centers of the two fibers and the cantilever tip displacement (the sound direction).

Acoustic identification of buried underwater unexploded ordnance using a numerically trained classifier (L).

Using a finite element-based structural acoustics code, simulations were carried out for the acoustic scattering from an unexploded ordnance rocket buried in the sediment under 3 m of water. The simulation treated 90 rocket burial angles in steps of 2°. The simulations were used to train a generative relevance vector machine (RVM) algorithm for identifying rockets buried at unknown angles in an actual water/sediment environment.

Defect detection and localization in orthotropic wood slabs by inversion of dynamic surface displacements.

The nondestructive evaluation inversion and generalized force-mapping techniques developed and demonstrated for isotropic thin plates by Bucaro et al. [(2004). "Detection and localization of inclusions in plates using inversion of point actuated surface displacements," J.