Emerging therapies in Multiple Myeloma: Leveraging immune checkpoint inhibitors for improved outcomes.

Background:: Multiple Myeloma is a hematological malignancy characterized by the proliferation of clonal plasma cells and associated with severe clinical manifestations. Despite advancements in diagnosis and management, Multiple Myeloma remains incurable, necessitating further research into more effective therapies.

Aim:: The primary objective of this review is to provide an informative and critical summary of the Multiple Myeloma microenvironment, and emerging revolutionary therapeutic approaches with potential combination therapy to improve the quality of life for Multiple Myeloma patients.

A Theoretically Informed Process Evaluation in Parallel to a Feasibility Study of a Complex Oral Health Intervention Using NICE Guidelines in a Care Home Setting.

Background: A theoretically informed process evaluation was undertaken in parallel to a study examining the feasibility of an oral health intervention based on an existing guideline for care homes. The objectives were to explore the factors that influenced the implementation of the intervention in order to understand the potential pathway to impact. The research team initially utilised Pfadenhauer et al.

Hydrogeochemical investigation and water quality assessment of the Indus River in the semiarid region of Ladakh, India.

The decline in water quality, particularly in river water, is a significant concern, especially in semi-arid areas and tourist destinations such as Ladakh. Periodic assessment of water quality could be a crucial step for ensuring its potability and serve as a foundation for formulating effective policies for sustainable water resource management. Consequently, this research aimed to analyze the periodic variations in the water quality of Indus River for domestic and agricultural use, focusing on the impact of geochemical processes within the basin.

Setting the context for a complex dental intervention of role substitution in care homes: Initial process evaluation findings.

Objectives: SENIOR (uSing rolE-substitutioN In care homes to improve oRal health) is a randomised controlled trial designed to determine whether role substitution could improve oral health for this population. A parallel process evaluation was undertaken to understand context. This paper reports on the first phase of the process evaluation.

Using a theoretically informed process evaluation alongside a trial to improve oral health for care home residents.

Background: Poor oral health is common among older adults residing in care homes impacting their diet, quality of life, self-esteem, general health and well-being. The care home setting is complex and many factors may affect the successful implementation of oral care interventions. Exploring these factors and their embedded context is key to understanding how and why interventions may or may not be successfully implemented within their intended setting.

Comprehensive design considerations for a new hospital gown: a patient-oriented qualitative study.

Background: The standard hospital gown has remained relatively unchanged despite reports that it is uncomfortable, embarrassing to wear and compromises patients' dignity. The objective of this qualitative study was to explore the experiences and perspectives of stakeholders involved in the gown life cycle.

Methods: We conducted a constructivist, qualitative interview study with a patient-oriented lens.

Significance of Visible Non-Invasive Risk Attributes for the Initial Prediction of Heart Disease Using Different Machine Learning Techniques.

Introduction: Heart disease is emerging as the single most critical cause of death worldwide and is one of the costliest chronic conditions.

Purpose: Stimulated by the increasing heart disease mortality rate incidents, an effective, low-cost, and reliable heart disease risk evaluation model is developed using significant non-invasive risk attributes. The significant non-invasive risk attributes like (age, systolic BP, diastolic BP, BMI, hereditary factor, smoking, alcohol, and physical inactivity) are identified by the help of medical domain experts, and their reliability in heart disease prediction is investigated through different feature selection techniques.

Prevalence of erectile dysfunction and associated factors among males visiting family medicine clinics in a Tertiary Care Hospital in Karachi, Pakistan.

Background: The burden of erectile dysfunction (ED) among the developed countries is found to be quite high. However, there is a paucity of data among developing countries to know its actual burden and factors associated with it.

Methods: The current study is cross-sectional and was conducted in Family Medicine clinics of Liaquat National Hospital during May 2017-January 2018.

Primary Care Physicians' Knowledge, Perceptions, and Comfort Level in Managing Patients Fasting in Ramadan.

Once a year, Muslims fast from dawn to sunset during the month of Ramadan. While fasting has many positive health implications, it may pose risks to individuals with underlying health issues. Despite the exemption from fasting for those who are ill, many Muslims with chronic conditions choose to fast.