Publications by authors named "Saif Laljee"
Article Synopsis
- During meiosis, double strand breaks (DSBs) are repaired preferentially between homologous chromosomes, relying on proteins Rad51 and Dmc1 for interhomolog bias and meiotic recombination.
- In dmc1Δ mutants, Rad51 is inhibited, leading to prophase arrest due to unresolved DSBs, with this inhibition dependent on the kinase Mek1 acting through two mechanisms that prevent Rad51’s accessory factor Rad54 from forming complexes.
- This study reveals that Mek1 phosphorylates Hed1, strengthening its ability to suppress Rad51 activity, thus ensuring proper chromosome crossover and stability during meiosis.