Publications by authors named "Saif Alimohamed"
Article Synopsis
- Cytokine storms caused by COVID-19 can lead to severe health issues, particularly in cancer patients undergoing immunotherapy due to heightened immune responses.
- A study involving over 12,000 cancer patients aimed to explore how baseline immunosuppression and immunotherapy affect the severity of COVID-19 and the likelihood of cytokine storms.
- Results indicated no significant differences in COVID-19 severity or cytokine storm occurrence among patients receiving immunotherapy compared to those not receiving any cancer treatment prior to their COVID-19 diagnosis.
Gene fusions frequently result from rearrangements in cancer genomes. In many instances, gene fusions play an important role in oncogenesis; in other instances, they are thought to be passenger events. Although regulatory element rearrangements and copy number alterations resulting from these structural variants are known to lead to transcriptional dysregulation across cancers, the extent to which these events result in functional dependencies with an impact on cancer cell survival is variable.
View Article and Find Full Text PDFArticle Synopsis
- Single-cell gene expression studies in mammalian tissues reveal important stage-specific molecular processes that are crucial for understanding different cell types and their developmental pathways.
- The authors propose the creation of a Pediatric Cell Atlas to be integrated into the Human Cell Atlas consortium, which will create detailed single-cell profiles of gene expression in human tissues and organs.
- This Pediatric Cell Atlas will enhance existing research on adults and development, offering valuable insights into pediatric health issues and the genetic and environmental factors affecting health throughout one's lifetime.