Publications by authors named "Saidulu Mattappally"
Article Synopsis
- Functional myocardium from human induced pluripotent stem cells (hiPSCs) has potential applications in cardiac disease modeling, drug testing, and heart repair, but hiPSC-derived cardiomyocytes lack maturity.
- Mechanical (cyclic stretch) and electrical stimulation were applied to hiPSC-derived cardiomyocyte spheroids to enhance their maturation both structurally and functionally.
- Results showed improved maturation markers, ultrastructure, and the ability to respond to electrical signals more effectively in the stimulated spheroids compared to unstimulated ones.
