Publications by authors named "Saida Said"
Article Synopsis
- Cervical cancer in India is largely caused by HPV and has high morbidity and mortality rates, emphasizing the need for understanding regional HPV prevalence for effective public health strategies.
- A systematic review and meta-analysis examined 17 studies with 2,529 cervical cancer cases, finding a pooled HPV prevalence of 85%, but noted substantial regional variations across different parts of India.
- Results indicate the importance of further research due to the complex epidemiology of HPV, as significant differences in prevalence were observed in various geographic zones within the country.
Bacterial members of the neurotransmitter:sodium symporter (NSS) family perform Na(+)-dependent amino-acid uptake and extrude H(+) in return. Previous NSS structures represent intermediates of Na(+)/substrate binding or intracellular release, but not the inward-to-outward return transition. Here we report crystal structures of Aquifex aeolicus LeuT in an outward-oriented, Na(+)- and substrate-free state likely to be H(+)-occluded.
View Article and Find Full Text PDFSerotonergic neurotransmission is modulated by the membrane-embedded serotonin transporter (SERT). SERT mediates the reuptake of serotonin into the presynaptic neurons. Conformational changes in SERT occur upon binding of ions and substrate and are crucial for translocation of serotonin across the membrane.
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