Publications by authors named "Said Rouhani"
Purpose: To evaluate the predictive value of EEG reactivity assessment and confounders for neurological outcome after cardiac arrest.
Methods: All consecutive patients admitted in a tertiary cardiac arrest center between 2007 and 2016 still alive 48 h after admission with at least one EEG recorded during coma. EEG reactivity was defined as a reproducible waveform change in amplitude or frequency following standardized stimulation.
Article Synopsis
- - The study aimed to evaluate inflammation in the lungs of patients suspected to have obstructive sleep apnea (OSA) by measuring exhaled nitric oxide (NO) using a specific two-compartment model that corrects for certain back-diffusion issues.
- - Ninety-five patients underwent various tests, and results showed significantly higher levels of alveolar NO in OSA patients compared to those without OSA, indicating a strong correlation between NO levels, the severity of sleep apnea (measured by AHI), and low oxygen levels during sleep.
- - The findings suggest that increased levels of alveolar NO are linked to worse oxygen desaturation at night in OSA patients, highlighting a potential connection between airway inflammation and intermittent lack of oxygen during sleep
Article Synopsis
- The study explores the characteristics of obstructive sleep apnea (OSA) in elderly (≥65 years) compared to younger patients, focusing on its connection to high blood pressure, coronary artery disease, and heart arrhythmias.
- The research involved adult patients who were assessed for OSA severity through sleep studies, revealing a higher prevalence and severity of OSA in the elderly group compared to younger individuals.
- Findings suggest that there is a stronger correlation between OSA severity and hypertension in younger patients, highlighting the need for early screening for OSA in younger populations and further investigation into OSA severity in older adults without obesity.*
Among all vectors designed for gene therapy purposes, adenovirus appears to be the most efficient in vivo vehicle to transduce the broadest spectrum of cellular targets. However, the deleterious immunogenicity of this viral vector impedes its use in chronic diseases. Non-viral vectors, such as naked DNA, are attractive alternatives for safety and technical issues, such as scale-up production.
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