Publications by authors named "Said M Daboor"

Biofilm infections are hard to manage using conventional antibiotic treatment regimens because biofilm structures discourage antibiotics from reaching the entire bacterial community and allow pathogen cells to persistently colonize and develop a plethora of tolerance mechanisms towards antibiotics. Moreover, the dispersed cells from biofilms can cause further complications by colonizing different sites and establishing new cycles of biofilms. Previously, we showed that alginate lyase enzyme (AlyP1400), purified from a marine Pseudoalteromonas bacterium, reduced Pseudomonas aeruginosa biofilm biomass and boosted bactericidal activity of tobramycin by degrading alginate within the biofilm extracellular polymeric substances matrix.

View Article and Find Full Text PDF

Background: Pseudomonas aeruginosa forms antibiotic-resistant biofilms that are responsible for the treatment failure or relapses of the bacterial infections in the lungs of patients with cystic fibrosis (CF). The alginate lyases that target extracellular polysaccharide alginate of P. aeruginosa biofilms are promising therapeutic candidates for treatment of P.

View Article and Find Full Text PDF

biofilms are typically associated with the chronic lung infection of cystic fibrosis (CF) patients and represent a major challenge for treatment. This opportunistic bacterial pathogen secretes alginate, a polysaccharide that is one of the main components of its biofilm. Targeting this major biofilm component has emerged as a tempting therapeutic strategy for tackling biofilm-associated bacterial infections.

View Article and Find Full Text PDF
Article Synopsis
  • - The study explored the antimicrobial properties of Spirulina platensis, a type of cyanobacteria, and its ability to produce effective substances against various bacteria and fungi.
  • - Different extraction methods were used to purify the antimicrobial compound, which was confirmed through techniques like thin layer chromatography and various spectrometry methods, revealing its chemical structure.
  • - Results showed that the isolated compound had significant activity against both Gram-positive and Gram-negative bacteria, especially E. coli and Pseudomonas aeruginosa, indicating that cyanobacteria could serve as a promising source for new antimicrobial agents.
View Article and Find Full Text PDF