Design, Synthesis, in vitro and in silico Characterization of 2-Quinolone-L-alaninate-1,2,3-triazoles as Antimicrobial Agents.

Due to the ever-increasing antimicrobial resistance there is an urgent need to continuously design and develop novel antimicrobial agents. Inspired by the broad antibacterial activities of various heterocyclic compounds such as 2-quinolone derivatives, we designed and synthesized new methyl-(2-oxo-1,2-dihydroquinolin-4-yl)-L-alaninate-1,2,3-triazole derivatives via 1,3-dipolar cycloaddition reaction of 1-propargyl-2-quinolone-L-alaninate with appropriate azide groups. The synthesized compounds were obtained in good yield ranging from 75 to 80 %.

Crystal structure, Hirshfeld surface analysis and inter-action energy and DFT studies of 4-[(prop-2-en-1-yl-oxy)meth-yl]-3,6-bis-(pyridin-2-yl)pyridazine.

The title compound, CHNO, consists of a 3,6-bis-(pyridin-2-yl)pyridazine moiety linked to a 4-[(prop-2-en-1-yl-oxy)meth-yl] group. The pyridine-2-yl rings are oriented at a dihedral angle of 17.34 (4)° and are rotated slightly out of the plane of the pyridazine ring.

Synthesis and Downstream Reactions of 2-(Triphenylphosphino)-4,5-dicarbomethoxy-1,3-diselenole Tetrafluoroborate: X-ray Crystal Structure of a Nitroso Derivative of a 2-Ylidene-1,3-diselenole Stabilized by an Intramolecular O.Se Interaction.

The title 1,3-diselenole Wittig reagent 9 has been synthesised by a new, efficient route from readily-available starting materials and reacted with a variety of functionalized aldehydes to form the corresponding 2-ylidene-1,3-diselenones 12 in respectable yields. X-ray analysis of a nitrosated derivative 14e, prepared by the reaction of 12e with isoamyl nitrite, has provided the first direct evidence for the stabilization of such systems by intramolecular oxygen-selenium interactions.