RNAknot: A new algorithm for RNA secondary structure prediction based on genetic algorithm and GRASP method.

The prediction of the optimal secondary structure for a given RNA sequence represents a challenging computational problem in bioinformatics. This challenge becomes harder especially with the discovery of different pseudoknot classes, which is a complex topology that plays diverse roles in biological processes. Many recent studies have been proposed to predict RNA secondary structure with some pseudoknot classes, but only a few of them have reached satisfying results in terms of both complexity and accuracy.