Managing Arrhythmias in Cardiogenic Shock: Insights Into Milrinone and Dobutamine Therapy.

Shock is a state of inadequate perfusion that affects vital organs. Cardiogenic shock (CS) predisposes patients to various arrhythmias. The adverse effect depends on intervention and pharmacogenomics.

A novel comprehensive approach to soil and water conservation: integrating morphometric analysis, WSA, PCA, and CoDA-PCA in the Naama sub-basins case study, Southwest of Algeria.

This research paper presents a detailed investigation into the morphometric characteristics of sub-basins within the Naama region of Algeria, aiming to prioritize areas vulnerable to soil erosion and runoff risks. Focusing on five key sub-basins that collectively represent 75% of the Wilaya of Naama, the study employs a comprehensive methodological framework, integrating morphometric analysis (MA), weighted sum analysis (WSA), principal component analysis (PCA), and the novel approach of compositional data analysis (CoDA). Through the rigorous evaluation of sixteen distinct morphometric parameters selected based on their relevance to hydrological and geomorphological processes that influence erosion and runoff, this research provides a nuanced understanding of the factors influencing erosion susceptibility within each sub-basin.

Simultaneously quantifying a novel five-component anti- migraine formulation containing ergotamine, propyphenazone, caffeine, camylofin, and mecloxamine using UV spectrophotometry and chemometric models.

This study presents a new method for simultaneously quantifying a complex anti-migraine formulation containing five components (ergotamine, propyphenazone, caffeine, camylofin, and mecloxamine) using UV spectrophotometry and chemometric models. The formulation presents analytical challenges due to the wide variation in component concentrations (ERG: PRO: CAF: CAM: MEC ratio of 0.075:20:8:5:4) and highly overlapping UV spectra.

State of the art of real-life concentration monitoring of rifampicin and its implementation contextualized in resource-limited settings: the Tanzanian case.

The unique medical and socio-economic situation in each country affected by TB creates different epidemiological contexts, thus providing exploitable loopholes for the spread of the disease. Country-specific factors such as comorbidities, health insurance, social stigma or the rigidity of the health system complicate the management of TB and the overall outcome of each patient. First-line TB drugs are administered in a standardized manner, regardless of patient characteristics other than weight.

Toward a Clinical Decision Support System for Monitoring Therapeutic Antituberculosis Medical Drugs in Tanzania (Project TuberXpert): Protocol for an Algorithm' Development and Implementation.

Background: The end tuberculosis (TB) strategy requires a novel patient treatment approach contrary to the one-size-fits-all model. It is well known that each patient's physiology is different and leads to various rates of drug elimination. Therapeutic drug monitoring (TDM) offers a way to manage drug dosage adaptation but requires trained pharmacologists, which is scarce in resource-limited settings.

Accelerated Hypofractionated Radiotherapy for Locally Advanced NSCLC: A Systematic Review From the International Association for the Study of Lung Cancer Advanced Radiation Technology Subcommittee.

Introduction: Accelerated hypofractionated radiotherapy has gained increasing interest for locally advanced NSCLC, as it can potentially increase radiobiologically effective dose and reduce health care resource utilization. Nevertheless, there is sparse prospective evidence supporting routine use of accelerated hypofractionation with or without concurrent chemotherapy. For this reason, the International Association for the Study of Lung Cancer Advanced Radiation Technology Subcommittee conducted a systematic review of prospective studies of accelerated hypofractionation for locally advanced NSCLC.

Tips for success, managing the paediatric patient in radiology.

Paediatric radiology is a fascinating and diverse field of medicine with many opportunities to gain expertise in a range of imaging modalities and body areas. Working with children makes imaging both rewarding and challenging, due to the wide range of patient ages encountered and the inherent variation in developmental needs. This requires a patient-focussed approach to manage their anxiety and ensure cooperation of the patient and their carers.

Obesity and its related factors among university medical students in Syria: A cross-sectional study.

Introduction: Obesity is a worldwide pandemic that has many contributing factors. There is very scarce data available on this issue for the population in Syria. We aim to evaluate the body mass index and related obesity rates of medical students as they are the role model for the general population.

The Prevalence of Mycobacterium Tuberculosis Infection in Saudi Arabia: A Systematic Review and Meta-analysis.

The prevalence of Tuberculosis (TB) serves as a pivotal metric, reflecting the TB burden within a specific demographic. It quantifies the number of individuals affected by either active TB disease or latent TB (LTBI). Such data is crucial for assessing the efficacy of TB control interventions and determining the demand for diagnostic and treatment services.

COVID-19 and malaria co-infection: a systematic review of clinical outcomes in endemic areas.

Background: COVID-19 and malaria cause significant morbidity and mortality globally. Co-infection of these diseases can worsen their impact on public health. This review aims to synthesize literature on the clinical outcomes of COVID-19 and malaria co-infection to develop effective prevention and treatment strategies.

Evaluation of the immunization of camels with vaccine (RB51) in Egypt.

Background: Brucellosis is a highly contagious zoonotic disease caused by an intracellular facultative microorganism termed spp. Control of brucellosis depends on test and slaughter policy as well as vaccination programs.

Aim: Estimation of the cell-mediated immunity (CMI) [total leukocytic count (TLC), phagocytic activity, phagocytic index, interleukin 6 (IL-6), and tumor necrosis factor-alpha (TNF-α)] in camels after vaccination with RB51 using real-time polymerase chain reaction (PCR).

Apparent Anomalous Temperature Dependence of Self-Diffusion Studied by Pulsed-Field Gradient Nuclear Magnetic Resonance and Thermodynamic Modeling.

The self-diffusivity of cyclohexane and -octane adsorbed in hierarchical zeolite monoliths has been investigated by using PFG-NMR. In these samples, the intrinsic FAU-X zeolite microporosity combines with a complex macroporous network composed of aggregated zeolite nanocrystals. As temperature is increased, cyclohexane self-diffusivity apparently decreases, reaches a minimum, and then starts increasing upon further increasing the temperature.

Characterising sources of PM exposure for school children with asthma: a personal exposure study across six cities in sub-Saharan Africa.

Background: Air pollution is the second largest risk to health in Africa, and children with asthma are particularly susceptible to its effects. Yet, there is a scarcity of air pollution exposure data from cities in sub-Saharan Africa. We aimed to identify potential exposure reduction strategies for school children with asthma living in urban areas in sub-Saharan Africa.

Silicosis, tuberculosis and silica exposure among artisanal and small-scale miners: A systematic review and modelling paper.

An estimated 44 million artisanal and small-scale miners (ASM), largely based in developing economies, face significant occupational risks for respiratory diseases which have not been reviewed. We therefore aimed to review studies that describe silicosis and tuberculosis prevalence and respirable crystalline silica (RCS) exposures among ASM and use background evidence to better understand the relationship between exposures and disease outcomes. We searched PubMed, Web of Science, Scopus and Embase for studies published before the 24th March 2023.

Occipital encephalocele: Presentation of case.

Introduction: Encephalocele is defined as the externalization of brain tissue and/or meninges from the skull through a congenital bony defect. It is one of the most severe neural tube defects.

Case Presentation: We report a female newborn, weighing 2800 g, APGAR score 8/10.

Factors Associated with Anxiety During COVID-19 Pandemic and Its Association with Hypertension in Saudi Arabia.

Objective: Patients with chronic diseases such as hypertension (HTN) are considered a vulnerable group, and they are prone to anxiety and other psychological conditions during pandemics. Very few reports discussed factors related to anxiety and how it is associated with HTN during COVID-19 pandemic. In this project, we aimed to identify the prevalence of anxiety among hypertensive patients in Saudi Arabia during the COVID-19 pandemic.

Never too soon to be thinking about heparin-induced thrombocytopenia! A case report of early onset heparin-induced thrombocytopenia.

Heparin-induced thrombocytopenia (HIT) is a serious complication that can affect a small percentage of patients receiving heparin. Atypical HIT presentations like delayed onset HIT have been described. We present an atypical case of early onset HIT in a patient presenting with ACS with no prior heparin exposure and shed light on the various atypical HIT and HIT-like presentations.

Digital health in the era of COVID-19: Reshaping the next generation of healthcare.

COVID-19 is one of the most deadly diseases to have stricken us in recent decades. In the fight against this disease, governments and stakeholders require all the assistance they can get from various systems, including digital health interventions. Digital health technologies are supporting the tracking of the COVID-19 outbreak, diagnosing patients, expediting the process of finding potential medicines and vaccines, and disinfecting the environment, The establishment of electronic medical and health records, computerized clinical decision support systems, telemedicine, and mobile health have shown the potential to strengthen the healthcare system.