[Experimental evaluation of the brucellosis therapeutic vaccine efficacy].

Use of antibiotics can't completely solve the problem of brucellosis treatment, especially its chronic forms, because antibacterial preparations do not eliminate main pathogenetic factor of the disease--sensibilization of the macroorganism. It makes actual the question about complex immuno- and antibacterial therapy. Long-term clinical experience proved high effectiveness of a therapeutic brucellosis vaccine.

[Electrophoretic mobility and energy charge of the adenyl system of blood lymphocytes in guinea pigs immunized against plague with strain Yersinia pestis ev subcultures with different immunogenicity].

The injection of highly immunogenic vaccine strain Yersinia pestis EV, line NIIEG, into guinea pigs was accompanied, as early as 24 hours after this injection, by a drop in the electrophoretic mobility of the main amount of lymphocytes, significant shifts in the content and quantitative relation of adenine nucleotides in the mixed lymphocyte population, as well as T and B lymphocytes after their preparative electrophoretic sorting. The immunizatiom of guinea pigs with strain EV of the Japanese line, possessing faint immunogenic properties, produced few changes in the electrophoretic mobility of lymphocytes; no significant changes in the energy charge of the adenylate system of lymphocytes and their subpopulations in comparison with intact animals were established. The study of the metabolic processes in lymphocytes and their populations makes it possible to give more precise characterization to evaluate the prospects of various vaccine preparations.

[Comparative study of the diagnostic value of new cholera eltor bacteriophages ctx+, ctx-, and KhDF-3, 4, and 5].

The comparative evaluation of the diagnostic value of new cholera eltor bacteriophages ctx+ and ctx-, as well as monophages X[symbol: see text]-3, 4, 5, demonstrated their high activity and specificity. Using of these bacteriophages epidemic potential of 95% Vibrio cholerae eltor strains ctx+ and 84.5% of V.

[Diagnostic value of a novel nutrient medium for isolation and cultivation of pathogens causing enteric yersiniosis and pseudotuberculosis].

A new nutrient medium for isolation and cultivation of the causative agents of enteric yersiniosis and pseudotuberculosis was found to have advantages over Endo medium in its differentiating and inhibiting properties. This medium permitted the easy differentiation of Yersinia pseudotuberculosis from Y. enterocolitica, as well as from Escherichia coli, Shigella flexneri, Klebsiella pneumoniae, K.

[The sources of active forms of oxygen in the normal oral tissues and in pathology].

In the experiment on rats the changes of the superoxydanionradical production from microsomal and mitochondrial oxidation and tissue phagocytes of the saliva gland and parodontium in contact sialadenitis, spontaneous parodontitis, after ionizing radiation have been investigated. It is supposed that an increase or decrease of superoxydanionradical production from different sources demands a differentiated corrective approach.