Publications by authors named "Sai-Yin Cheungc"
EBioMedicine
December 2018
Article Synopsis
- Researchers explored how amyloid precursor protein (APP), commonly linked to Alzheimer's, also influences breast cancer progression via its cleavage into a fragment called soluble APPα (sAPPα).
- They found that both full-length APP and sAPPα promote breast cancer cell migration and growth, with this process being driven by the enzyme ADAM10.
- The study suggests that high levels of APP and ADAM10 in non-luminal breast cancer patients are linked to poorer survival rates, indicating that targeting APP or ADAM10 could be an effective treatment strategy.
