Publications by authors named "Sai-Li Zeng"
In general, non-small cell lung cancer patients with epidermal growth factor receptor (EGFR) mutations respond to tyrosine kinase inhibitors (TKIs). However, most patients experience resistance within 1-2 years after treatment. The histological explanation for the acquired resistance is that malignant transformation occurs during cancer treatment.
View Article and Find Full Text PDF[Effects of simvastatin on pulmonary fibrosis and endothelial - mesenchymal transition in the pulmonary fibrosis tissue of rats].
Zhongguo Ying Yong Sheng Li Xue Za Zhi
September 2021
Article Synopsis
- The study aimed to evaluate the impact of simvastatin on pulmonary fibrosis in rats, specifically looking at markers of fibrosis and vascular integrity (VE-cadherin, vimentin, and alpha-SMA).
- A total of 60 male rats were divided into four groups: one control group, one fibrosis group (bleomycin treated), and two simvastatin treatment groups (5 mg and 10 mg).
- Results showed that simvastatin significantly reduced fibrosis markers and increased VE-cadherin levels compared to the fibrosis group, particularly at the highest dose (10 mg) after 28 days of treatment.