Robust adaptive beamforming based on zone orthogonal constraint and steering vector estimation.

This Letter solves steering vector estimation under mismatch for adaptive beamforming. The proposed beamformer implements a stepwise estimation of steering vector, and zone orthogonal constraint is added first based on adaptive constraint framework from Khabbazibasmenj [IEEE Trans. Signal Process.

Dose-dependent Effects of PRC2 and HDAC Inhibitors on Cardiomyocyte Hypertrophy Induced by Phenylephrine.

Introduction: Postnatal cardiomyocytes respond to stress signals by hypertrophic growth and fetal gene reprogramming, which involves epigenetic remodeling mediated by histone methyltransferase polycomb repressive complex 2 (PRC2) and histone deacetylases (HDACs). However, it remains unclear to what extent these histone modifiers contribute to the development of cardiomyocyte hypertrophy.

Methods: Neonatal rat ventricular myocytes (NRVMs) were stimulated by phenylephrine (PE; 50μM) to induce hypertrophy in the presence or absence of the PRC2 inhibitor GSK126 or the HDACs inhibitor Trichostatin A (TSA).

Three-Dimensional Imaging of Circular Array Synthetic Aperture Sonar for Unmanned Surface Vehicle.

Synthetic aperture sonar (SAS) and interferometric synthetic aperture sonar (InSAS) have a range layover phenomenon during underwater observation, the AUV-mounted circular synthetic aperture sonar (CSAS) system, that insonifies targets using multiple circular scans that vary in height and can eliminate the layover phenomenon. However, this observation method is time-consuming and difficult to compensate. To solve this problem, the circular array synthetic aperture sonar (CASAS) based on the equivalent phase center was established for unmanned surface vehicles.

NAP1L5 Promotes Nucleolar Hypertrophy and Is Required for Translation Activation During Cardiomyocyte Hypertrophy.

Pathological growth of cardiomyocytes during hypertrophy is characterized by excess protein synthesis; however, the regulatory mechanism remains largely unknown. Using a neonatal rat ventricular myocytes (NRVMs) model, here we find that the expression of nucleosome assembly protein 1 like 5 (Nap1l5) is upregulated in phenylephrine (PE)-induced hypertrophy. Knockdown of Nap1l5 expression by siRNA significantly blocks cell size enlargement and pathological gene induction after PE treatment.

Preparation and Photocatalytic Application of the Composites PMo/AgNPs Based on Polyoxometalates.

Supported catalysts, consisting of PMo immobilized on silver nanomaterials at different recombination time and the silver nanomaterials with different template sodium citrate amount characterized by FT-IR, XRD, SEM, UV-vis and other test methods. The results show that the AgNPs are relatively uniformed with sizes between 100-300 nm when the sodium citrate addition amount is 9.0 mL.

Oncogenic AURKA-enhanced N-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells.

RNase III DROSHA is upregulated in multiple cancers and contributes to tumor progression by hitherto unclear mechanisms. Here, we demonstrate that DROSHA interacts with β-Catenin to transactivate STC1 in an RNA cleavage-independent manner, contributing to breast cancer stem-like cell (BCSC) properties. DROSHA mRNA stability is enhanced by N-methyladenosine (mA) modification which is activated by AURKA in BCSCs.