Association between accelerated biological aging and colorectal cancer: a cross-sectional study.

Background: Biological age (BA) is regarded as a more accurate marker of aging than chronological age and is commonly used to assess associations with age-related diseases. The relationship between BA measures and the colorectal cancer (CRC) has not yet been investigated.

Methods: This study utilized data from the National Health and Nutrition Examination Survey.

Spatial Variation in Food Web Structures, Energy Flows, and System Attributes Along the Pearl River and Their Indications of Protection and Restoration.

River ecosystems are facing significant degradation from human activities, which impact both biotic (e.g., fish and invertebrates) and abiotic components (e.

The complete mitogenome of (Yu & Wang, 2022) (Lepidoptera: Lecithoceridae) and its phylogenetic implications.

The complete mitochondrial genome sequence of has been obtained based on the Illumina next-generation sequencing technology, which is currently the first reported mitogenome in the subfamil Torodorinae. The mitogenome is 15,590 bp in length, consisting of 13 PCGs, 22 tRNAs, 2 rRNA genes and one non-coding A + T rich control region. The phylogenetic tree constructed based on the maximum likelihood (ML) methods using the whole genome sequences does well support for the sister branch relationship between and .

An integrated colorimetric biosensing platform containing microneedle patches and aptasensor for histamine monitoring in seafood.

Excessive histamine in spoiled seafood poses considerable health hazards to consumers, yet its detection is challenging due to complicated sample preparation and detection methodologies. Herein, an integrated colorimetric platform containing Poly (vinyl alcohol) (PVA)/hyaluronic acid (HA) microneedle patches-assisted extraction and aptasensor-based detection was reported. The developed PVA/HA microneedle patches facilitated on-site histamine extraction from seafood through a two-minute press-and-peel procedure.

Harnessing Solar-Salinity Synergy with Porphyrin-Based Ionic Covalent-Organic-Framework Membranes for Enhanced Ionic Power Generation.

Nature seamlessly integrates multiple functions for energy conversion, utilizing solar energy and salinity gradients as the primary drivers for ionic power generation. The creation of artificial membranes capable of finely controlling ion diffusion within nanoscale channels, driven by diverse forces, remains a challenging endeavor. In this study, we present an innovative approach: an ionic covalent-organic framework (COF) membrane constructed using chromophoric porphyrin units.

Deacetylation of BAP31 by sirtuin 2 attenuates apoptosis of hepatocytes induced by endoplasmic reticulum stress, in chronic alcoholic liver injury.

Background And Purpose: Endoplasmic reticulum (ER) stress is a crucial pathogenic mechanism in alcoholic liver disease (ALD). B-cell receptor-associated protein 31 (BAP31) can regulate ER homeostasis and anti-apoptosis, but the function and regulation of BAP31 in ALD are unclear. The purpose of this study is to investigate whether BAP31 deacetylation by sirtuin 2 could attenuate ER stress and apoptosis during ALD and to explore whether carnosol could alleviate ALD through the sirtuin 2/BAP31 pathway.

SERCA2 dysfunction accelerates angiotensin II-induced aortic aneurysm and atherosclerosis by induction of oxidative stress in aortic smooth muscle cells.

Background And Aim: Our previous research indicates that sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) dysfunction facilitates the phenotypic transformation of aortic smooth muscle cells (ASMCs) and intensifies aortic aneurysm through the regulation of calcium-dependent pathways and endoplasmic reticulum stress. Our hypothesis is that additional mechanisms are involved in aortic aneurysm and atherosclerosis induced by SERCA2 dysfunction from the perspective of ASMC phenotypic transformation.

Methods & Results: In SERCA2 dysfunctional mice and their control littermates, ASMCs were isolated to analyze protein expression and cell functions, and angiotensin II was infused into these mice that were backcrossed into LDL receptor deficient background to induce aortic aneurysm and atherosclerosis.

Visible-Light-Driven Carboxylative 1,2-Difunctionalization of C=C Bonds with Tetrabutylammonium Oxalate.

Herein, we report a visible-light-induced charge-transfer-complex-enabled dicarboxylation and deuterocarboxylation of C=C bonds with oxalate as a masked CO source under catalyst-free conditions. In this reaction, we disclosed the first example that the tetrabutylammonium oxalate could be able to aggregate with aryl substrates via π-cation interactions to form the charge transfer complexes, which subsequently triggers the single electron transfer from the oxalic dianion to the ammonium countercation under irradiation of 450 nm bule LEDs, releasing CO and CO radical anions. Diverse alkenes, dienes, trienes, and indoles, including challenging trisubstituted olefins, underwent dicarboxylation and anti-Markovnikov deuterocarboxylation with high selectivity to access valuable 1,2- and 1,4-dicarboxylic acids as well as indoline-derived diacids and β-deuterocarboxylic acids under mild conditions.

Dual-mode CRISPR/Cas12a-assisted fluorescent and lateral flow aptasensor based on a newly truncated aptamer for Fumonisin B1 detection.

As a Group 2B carcinogen, accurate and efficient detection for Fumonisin B1 (FB1) is essential. The emergence of aptamers presents a viable solution to meet this demand. In this study, a truncated aptamer named Apt40 was developed, showcasing remarkable binding affinity to FB1.

A regulatory network involving calmodulin controls phytosulfokine peptide processing during drought-induced flower abscission.

Drought stress substantially decreases crop yields by causing flowers and fruits to detach prematurely. However, the molecular mechanisms modulating organ abscission under drought stress remain unclear. Here, we show that expression of CALMODULIN2 (CaM2) is specifically and sharply increased in the pedicel abscission zone in response to drought and plays a positive role in drought-induced flower drop in tomato (Solanum lycopersicum).

Presence and sources of per- and polyfluoroalkyl substances (PFASs) in the three major rivers on Hainan Island.

Per- and polyfluoroalkyl substances (PFASs) have attracted considerable attention because of their toxicity, persistence and bioaccumulation potential. With the construction of the Hainan Free Trade Port and the rapid development of economy, environmental pollution on Hainan Island is becoming increasingly prominent. PFASs have been detected in the seawater and sediments of mangrove ecosystems on Hainan Island.

Association of Hypokalemia With Mortality in Patients Undergoing Hemodialysis: A Systematic Review and Meta-Analysis.

Background: Potassium imbalance, particularly hypokalemia, is a critical risk factor for adverse outcomes in patients undergoing hemodialysis (HD). However, the association between hypokalemia and mortality is unclear.

Methods: For this systematic review and meta-analysis, we assessed the association between hypokalemia and mortality in patients undergoing HD.

Dominant spoilage bacteria in crayfish alleviate ultrasonic stress through mechanosensitive channels but could not prevent the process of membrane destruction.

Although there have been many studies on the efficacy of ultrasonic inactivation, the stress resistance mechanism of bacteria is still a challenge for complete ultrasonic inactivation. In this study, the dominant spoilage bacteria in crayfish, Shewanella baltica (S. baltica) and Aeromonas veronii (A.

A colorimetric biosensor composed of split aptamers and mannan oligosaccharide nanozyme to monitor synthetic His-tagged food biomolecules.

Food synthetic biology is garnering increasing attention for its potential to generate bioactive components. His-tag is one of the most popular tags used in food synthetic biology. Herein, His-tag, His-tagged proteins, and His-tagged peptides were adopted as the model targets, and a commonly used biosensor was developed to monitor His-tagged food biomolecules, using split aptamers as specific recognition probes and nanozyme as the transduction element.

Efficient Light-Driven Ion Pumping for Deep Desalination via the Vertical Gradient Protonation of Covalent Organic Framework Membranes.

Traditional desalination methods face criticism due to high energy requirements and inadequate trace ion removal, whereas natural light-driven ion pumps offer superior efficiency. Current synthetic systems are constrained by short exciton lifetimes, which limit their ability to generate sufficient electric fields for effective ion pumping. We introduce an innovative approach utilizing covalent-organic framework membranes that enhance light absorption and reduce charge recombination through vertical gradient protonation of imine linkages during acid-catalyzed liquid-liquid interfacial polymerization.

Optimizing Si─O Conjugation to Enhance Interfacial Kinetics for Low-Temperature Rechargeable Lithium-Ion Batteries.

With the growing demand for high-voltage and wide-temperature range applications of lithium-ion batteries (LIBs), the requirements for electrolytes have become increasingly stringent. While fluorination engineering has enhanced the performance of traditional solvent systems, it has also raised concerns regarding cost, environmental hazards, and low reduction stability. Through strategic molecular bond design, a novel class of low-temperature (LT) solvents-siloxanes-is identified, meeting the demands of LT and high-voltage applications in LIBs.

Artificial Cascade Transformation Biosystem for One-Pot Biomanufacturing of Odd-Numbered Neoagarooligosaccharides and d-Tagatose through Wiser Agarose Utilization.

The application of agarose oligosaccharides has garnered great attention, with their biological activities varying among different structures. However, it still meets a great bottleneck for the targeted production of odd-numbered neoagarooligosaccharides (NAOSs), such as neoagarotriose (NA3), due to the lack of one-step hydrolases. In this work, the α-agarase AgaA33 and β-galactosidase BgaD were synergistically used to prepare NA3 with agarose as a substrate.

ECM1 attenuates hepatic fibrosis by interfering with mediators of latent TGF-β1 activation.

Objective: Extracellular matrix protein 1 (ECM1) serves as a gatekeeper of hepatic fibrosis by maintaining transforming growth factor-β1 (TGF-β1) in its latent form. ECM1 knockout (KO) causes latent (L) TGF-β1 activation, resulting in hepatic fibrosis with rapid mortality. In chronic liver disease (CLD), ECM1 decreases with increasing CLD severity.

Development of a CRISPR/Cas12a-facilitated fluorescent aptasensor for sensitive detection of small molecules.

The integration of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and CRISPR-associated proteins (Cas) exhibits superior performance in biosensor construction. And the distinctive role of aptamers in target recognition has long been a focal point of research. Through the combination of Cas12a with cis-cleavage activity and aptamer with specific recognition, a simple and rapid fluorescent biosensor has been constructed.