Publications by Sai Srinivas Upadhyayula

Publications by authors named "Sai Srinivas Upadhyayula"

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Quantitative imaging of RAD51 expression as a marker of platinum resistance in ovarian cancer.

Michal M Hoppe Patrick Jaynes Joanna D Wardyn Sai Srinivas Upadhyayula Tuan Zea Tan

EMBO Mol Med

May 2021

Early relapse after platinum chemotherapy in epithelial ovarian cancer (EOC) portends poor survival. A-priori identification of platinum resistance is therefore crucial to improve on standard first-line carboplatin-paclitaxel treatment. The DNA repair pathway homologous recombination (HR) repairs platinum-induced damage, and the HR recombinase RAD51 is overexpressed in cancer.

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