Publications by authors named "Sai Spandana Chintapalli"

Availability of large and diverse medical datasets is often challenged by privacy and data sharing restrictions. Successful application of machine learning techniques for disease diagnosis, prognosis, and precision medicine, requires large amounts of data for model building and optimization. To help overcome such limitations in the context of brain MRI, we present GenMIND: a collection of generative models of normative regional volumetric features derived from structural brain imaging.

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Availability of large and diverse medical datasets is often challenged by privacy and data sharing restrictions. For successful application of machine learning techniques for disease diagnosis, prognosis, and precision medicine, large amounts of data are necessary for model building and optimization. To help overcome such limitations in the context of brain MRI, we present GenMIND: a collection of generative models of normative regional volumetric features derived from structural brain imaging.

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Generative adversarial networks (GANs) are one powerful type of deep learning models that have been successfully utilized in numerous fields. They belong to the broader family of generative methods, which learn to generate realistic data with a probabilistic model by learning distributions from real samples. In the clinical context, GANs have shown enhanced capabilities in capturing spatially complex, nonlinear, and potentially subtle disease effects compared to traditional generative methods.

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Article Synopsis
  • The study investigates the genetic links to the structure of the brain's folds by analyzing data from 40,169 individuals using MRI scans from the UK Biobank.
  • Researchers found 388 associations between regional brain folding and 77 genetic loci, with genes in these areas tied to brain development and functioning.
  • The findings also include an interactive 3D visualization to help explore these associations, emphasizing their potential for studying brain health and neuropsychiatric conditions in the future.
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