Phase 2 study of chidamide in combination with CAG and venetoclax-azacitidine in older patients with newly diagnosed acute myeloid leukemia.

Introduction: Older patients with acute myeloid leukemia (AML) respond poorly to standard induction therapy. DNA methyltransferases (DNMTs) and histone-deacetylases (HDACs) are key regulators of gene expression in cells and have been investigated as important therapeutic targets. However, their effects remains unclear as induction therapy for AML.

Coarse matching was sufficient to capture attention by working memory representations unless matching features with the target.

Background: In most theoretical frameworks, the effectiveness of attentional selection relies significantly on the perceptual similarity between the target template and visual input. Nevertheless, ambiguity exists surrounding whether attentional capture triggered by irrelevant representations in Working Memory (WM) is influenced by the perceptual similarity levels of features between WM content and its matching distractors.

Methods: We designed a hybrid WM and visual search task, varying such perceptual similarity of colors across three levels: exact, high-similar, and low-similar matching.

A phase 2 study of chidamide in combination with CAG and venetoclax-azacitidine in acute myeloid leukemia: Clinical safety, efficacy, and correlative analysis.

Acute myeloid leukemia (AML) is a highly heterogeneous hematopoietic malignancy characterized by elevated mortality. Epigenetic therapy plays an essential role in the treatment of AML. However, the clinical outcomes of the combination of multiple epigenetic agents and conventional chemotherapy remain unclear.

Research on glass imitation jade culture in the ancient Chinese Silk Road.

This paper undertakes a multi-dimensional exploration of the glass imitation jade culture under the context of the ancient Silk Road, tracing the historical trajectory of glass manufacturing technology from West Asia to China, especially after the Han Dynasty, when the flourishing trade along the Silk Road facilitated the integration of foreign glass craftsmanship with China's indigenous imitation jade tradition. This integration prompted Chinese glass artifacts to not only incorporate foreign techniques but also emphasize the texture and cultural symbolism of jade. Through systematic archaeological excavations and historical text analysis, this study delves into the unique phenomenon of glass imitation jade on the ancient Silk Road in China, providing detailed exposition on the formation, characteristics, and profound impact of this cultural practice.

Applications of Chitosan and its Derivatives in the Treatment of Osteoarthritis.

Osteoarthritis (OA) is a common joint disease, which is mainly characterized by the degeneration of articular cartilage, inflammation of the synovial membrane of the joint, and changes in the surrounding bone tissue. With the increase of age and weight, the incidence of OA gradually increases, which seriously affects the quality of life of patients. The primary pharmacological treatments for OA include analgesics and non-steroidal anti-inflammatory drugs.

Selective Photocatalytic C─H Oxidation Using All-Inorganic Perovskite Quantum Dots Encapsulated in UiO-Series MOFs.

All-inorganic cesium lead halide (CsPbX, X = Cl, Br, I) perovskite quantum dots (PeQDs) are successfully incorporated within the cages of zirconium-based UiO-series metal-organic frameworks (MOFs) using in situ ship-in-a-bottle method at room temperature under ambient conditions. The resulting mBPP-MOF, which includes the 4,4'-(2,2'-bipyridyl-5,5'-diyl)dibenzoic acid (HBPP) linker, features a larger cavity size than UiO-66 and UiO-67-bpy, allowing for uniform accommodation of PeQDs within its cages. This PeQDs@MOF hybrid heterostructure enhances the separation and transfer of photogenerated charges, enabling the synthesized CsPbBr@mBPP-MOF to demonstrate highly selective and stable performance in the photocatalytic oxidation of toluene under visible light irradiation at 395 nm.

Simultaneous unilateral thoracoscopic resection of bilateral pulmonary sequestration.

Background: Intra-lobar (ILS) and extra-lobar lung (ELS) sequestrations represent rare congenital lung malformations. Despite their benign nature, the lesions pose risks such as recurrent pulmonary infections, hemoptysis, congestive heart failure, and tumor development. Pulmonary sequestration (PS) typically manifests in two forms, ILS and ELS, with bilateral occurrence being exceptionally rare and mostly requiring bilateral thoracic surgery.

Application of Odd-Order Derivatives in Fourier Transform Nuclear Magnetic Resonance Spectroscopy toward Quantitative Deconvolution.

When Fourier transform (FT) spectrum peaks are overlapped, primary maxima of odd-order derivatives can be used to evaluate their independent intensities. We studied the feasibility of higher odd-order derivatives on Lorentzian peak shape and magnitude peak shape. Simulation studies for FT nuclear magnetic resonance (NMR) spectroscopy demonstrated good results toward quantitative deconvolution of overlapping FT spectrum peaks.

Clonal Hematopoiesis-Associated Gene Mutations Affect Acute Graft-Versus-Host Disease After Hematopoietic Stem Cell Transplantation in AML Patients.

BACKGROUND The relationship between clonal hematopoiesis (CH)-associated gene mutations and allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been extensively studied since next-generation sequencing (NGS) technology became widely available. However, research has mainly focused on the relationship between donor CH mutations and transplant prognosis, and research into the relationship between CH mutations in the recipient and acute graft-versus-host disease (aGVHD) is lacking. MATERIAL AND METHODS We analyzed NGS results and their correlation with aGVHD and prognosis in 196 AML patients undergoing allo-HSCT.

[Clinical Characteristics and Prognosis of Acute Myeloid Leukemia Patients with Gene Mutation].

Objective: To investigate the clinical characteristics, coexisting gene mutations and prognosis of acute myeloid leukemia (AML) patients with gene mutation.

Methods: The clinical data of 370 newly diagnosed AML patients treated in our hospital from January 2008 to January 2021 was analyzed retrospectively, the next-generation sequencing technology was used to detect the mutated genes in those patients. The clinical characteristics of AML patients with mutations, the co-mutated genes of mutations, and the effect of mutation on prognosis were analyzed.

Next-generation sequencing reveals relapse and leukemia-free survival risks in newly diagnosed acute myeloid leukemia treated with CAG regimen combined with decitabine.

Background: Acute myeloid leukemia (AML) is a heterogeneous hematopoietic malignancy whose prognosis is associated with several biomarkers. Decitabine, a deoxyribonucleic acid (DNA) methyltransferase (DNMT) inhibitor, combined with cytarabine, aclarubicin hydrochloride, and granulocyte colony-stimulating factor (DCAG), has been used in patients newly diagnosed with AML. This regimen has been especially used in older and fragile patients who are immunocompromised or have co-morbidities, as well as those with specific gene mutations.

Efficacy and prognostic factors of allogeneic hematopoietic stem cell transplantation treatment for adolescent and adult Tlymphoblastic leukemia /lymphoma: a large cohort multicenter study in China.

T lymphoblastic leukemia /lymphoma (T-ALL/LBL) is a rare and highly aggressive neoplasm of lymphoblasts. We evaluated 195 T-ALL/LBL adolescent and adult patients who received ALL-type chemotherapy alone (chemo,n = 72) or in combination with autologous hematopoietic stem cell transplantation(auto-HSCT,n = 23) or allogeneic hematopoietic stem cell transplantation(allo-HSCT,n = 100) from January 2006 to September 2020 in three Chinese medical centers. 167 (85.

Simultaneous occurrence of extralobar pulmonary sequestration, esophageal duplication, and bronchogenic cysts in a Chinese child: a rare case report.

The occurrence of simultaneous extralobar pulmonary sequestration, esophageal duplication, and bronchogenic cysts is relatively low. We report the case of a 9-month-old Chinese child who had a right lung cyst, detected and was closely monitored until birth. At age 9 months, contrast-enhanced computed tomography revealed right mediastinal extralobar pulmonary sequestration and two cysts.

[Venetoclax Combined with CACAG Regimen in the Treatment of Patients with Refractory/Relapse Acute Myeloid Leukemia: A Prospective Clinical Study].

Objective: To investigate the efficacy and safety of Venetoclax combined with CACAG regimen in treatment of patients with refractory/relapse acute myeloid leukemia(R/R AML).

Methods: The study was a singlecenter prospective clinical trial. The enrolled patients met the criteria for R/R AML.

AMSCN: A Novel Dual-Task Model for Automatic Modulation Classification and Specific Emitter Identification.

Specific emitter identification (SEI) and automatic modulation classification (AMC) are generally two separate tasks in the field of radio monitoring. Both tasks have similarities in terms of their application scenarios, signal modeling, feature engineering, and classifier design. It is feasible and promising to integrate these two tasks, with the benefit of reducing the overall computational complexity and improving the classification accuracy of each task.

Clinical effectiveness of sodium bicarbonate therapy on mortality for septic patients with acute moderate lactic acidosis.

This study aimed to explore the effectiveness of sodium bicarbonate (SB) administration on mortality in septic patients with acute moderate lactic acidosis (MLA). The large ICU database (MIMIC-IV) was retrospectively analyzed. Patients with sepsis and acute MLA were identified.

Effects of Different Types of Electric Fields on Mechanical Properties and Microstructure of Porcine Brain Tissues.

Electrotherapy plays a crucial role in regulating neuronal activity. Nevertheless, the relevant therapeutic mechanisms are still unclear; thus, the effects of electric fields on brain tissue's mechanical properties and microstructure need to be explored. In this study, focusing on the changes in mechanical properties and microstructure of porcine brain tissues under different types of electric fields, directional and alternating electric fields (frequencies of 5, 20, 50, and 80 Hz, respectively) integrate with a custom-designed indentation device.

Effectiveness of sodium bicarbonate infusion on mortality for elderly septic patients with acute metabolic acidosis.

This study aimed to explore the effectiveness of sodium bicarbonate (SB) infusion on mortality in elderly septic patients with acute metabolic acidosis (MA) and in other subgroups. Retrospective analysis of a large ICU database (MIMIC-IV) was performed. Elderly septic patients with acute MA were identified from MIMIC-IV.

Next-generation sequencing revealed factors associated with cumulative incidence of relapse and leukemia-free survival in patients with newly diagnosed acute myeloid leukemia.

Background: Several prognostic biomarkers have been validated for acute myeloid leukemia (AML), a heterogeneous hematopoietic malignancy. However, the factors associated with the cumulative incidence of relapse (CIR) and leukemia-free survival (LFS) in real-world patients with AML have not been well defined.

Methods: This study examined clinical and mutational data of 246 patients with newly diagnosed AML who received the traditional "3 ​+ ​7" regimen in PLA General Hospital from January 2008 to August 2020.

High Risk of Recurrence of Malignancy Noted in Four-day rATG Regimen After Allogeneic PBSCT From Matched Sibling Donors.

Hitherto, the optimal timing of rabbit anti-thymocyte globulin (rATG) in matched sibling donor peripheral blood stem cell transplantation (MSD-PBSCT) remains to be elucidated. We wanted to evaluate the effect of a new timing strategy of rATG in MSD-PBSCT patients on transplantation outcomes. In this prospective single-arm phase 2 clinical trial, 45 consecutive MSD-PBSCT patients were enrolled from February 1, 2019, to January 31, 2021.

Internal and external validation of machine learning-assisted prediction models for mechanical ventilation-associated severe acute kidney injury.

Background: Currently, very few preventive or therapeutic strategies are used for mechanical ventilation (MV)-associated severe acute kidney injury (AKI).

Objectives: We developed clinical prediction models to detect the onset of severe AKI in the first week of intensive care unit (ICU) stay during the initiation of MV.

Methods: A large ICU database Medical Information Mart for Intensive Care IV (MIMIC-IV) was analysed retrospectively.

Identification and Validation of Reliable Reference Genes for Gene Expression Studies in .

RT-qPCR is considered a rapid and reliable technique for analyzing gene expression. This technique is commonly used to analyze the expression of various genes at diverse transcriptional levels in different samples. However, few studies have characterized ornamental species for reliable reference genes.

Co-Administration with Voriconazole Doubles the Exposure of Ruxolitinib in Patients with Hematological Malignancies.

Background: Ruxolitinib is newly approved for glucocorticoid-refractory acute graft-versus-host disease (GVHD) in patients undergoing allo-geneic hematopoietic stem-cell transplantation (allo-HSCT), and voriconazole is commonly used in allo-HSCT recipients for the prophylaxis or treatment of invasive fungal infections (IFIs). Drug-drug interaction (DDI) may occur between them because their metabolic pathways overlap and can be inhibited by voriconazole, including cytochrome P450 (CYP) isozymes 3A4 and 2C9.

Objective: In the present study, we aimed to investigate the DDI between ruxolitinib and voriconazole in patients with hematological malignancies.