Repeat percutaneous rhizotomy for trigeminal neuralgia is not associated with an increased risk of postoperative complications.

Background And Objectives: Patients undergoing percutaneous rhizotomy for trigeminal neuralgia (TN) may require several procedures to manage their pain. However, it is not fully understood whether repeat procedures influence postoperative complication rates.

Methods: We retrospectively reviewed patients undergoing rhizotomy at our institution from 2011 to 2022.

Psychosurgery in Indian Scenario: Time to Think with Phronesis.

With advances in technology, neurosurgical procedures are being examined for potential use in psychiatric conditions. However, the use of neurosurgical procedures in psychiatry carries the baggage of memories of psychosurgery. Different neurosurgical techniques carry their characteristic safety, efficacy, and complication profile.

Homer1a regulates Shank3 expression and underlies behavioral vulnerability to stress in a model of Phelan-McDermid syndrome.

Mutations of SHANK3 cause Phelan-McDermid syndrome (PMS), and these individuals can exhibit sensitivity to stress, resulting in behavioral deterioration. Here, we examine the interaction of stress with genotype using a mouse model with face validity to PMS. In Shank3 mice, swim stress produces an altered transcriptomic response in pyramidal neurons that impacts genes and pathways involved in synaptic function, signaling, and protein turnover.

The Experience and Reactions towards Stage 1 COVID-19 among Junior Doctors in India.

Background: COVID-19 pandemic is the first modern pandemic and has occurred in an era of social media ubiquity. Despite being in stage 1 of the pandemic, and low numbers of patients, various emotional and behavioral changes were observed in junior doctors. This study was designed to assess the experience and reactions of junior doctors in a tertiary teaching hospital in North India and Tamil Nadu in the immediate aftermath of the nation-wide lockdown.

Implications of phase solubility/miscibility and drug-rich phase formation on the performance of co-amorphous materials: The case of Darunavir co-amorphous materials with Ritonavir and Indomethacin as co-formers.

The present study was designed to investigate the contribution of solid-state and the impact of composite drug-rich phase generated as a consequence of pH shift on the maximum achievable supersaturation of co-amorphous formulations. The co-amorphous phases of weak base-weak base-pair i.e.

Parkinsonism-hyperpyrexia syndrome: A case report and review of literature.

Parkinsonism-hyperpyrexia syndrome (PHS) is a rare but potentially life-threatening complication of the management of Parkinson's disease (PD). Central hypodopaminergic state which results due to abrupt withdrawal of dopaminergic medications in patients with PD is the postulated cause. Clinical manifestations of PHS are very akin to neuroleptic malignant syndrome (NMS).