Evoked Cortical Depolarizations Before and After the Amyloid Plaque Accumulation: Voltage Imaging Study.

Background: In Alzheimer's disease (AD), synaptic dysfunction is thought to occur many years before the onset of cognitive decline.

Objective: Detecting synaptic dysfunctions at the earliest stage of AD would be desirable in both clinic and research settings.

Methods: Population voltage imaging allows monitoring of synaptic depolarizations, to which calcium imaging is relatively blind.