Filaments and four ordered structures inside a neuron fire a thousand times faster than the membrane: theory and experiment.

The current action potential paradigm considers that all components beneath the neuron membrane are inconsequential. Filamentary communication is less known to the ionic signal transmission; recently, we have proposed that the two are intimately linked through time domains. We modified the atom probe-connected dielectric resonance scanner to operate in two-time domains, milliseconds and microseconds simultaneously for the first time.

Assessment of quality of life among advanced ovarian cancer patients in a tertiary care hospital in India.

Purpose: The study aims to record the quality of life (Qol) and its changes while ovarian cancer (OC) patients undergo debulking surgeries and chemotherapy in a tertiary care hospital of Eastern India.

Methods: Patients with advanced epithelial OC (FIGO stages III-IV) were recruited. They underwent primary/interval debulking surgeries with classical chemotherapy (adjuvant/neoadjuvant) of intravenous tri-weekly doses of paclitaxel + carboplatin.

Repeatability of tumor perfusion kinetics from dynamic contrast-enhanced MRI in glioblastoma.

Background: Dynamic contrast-enhanced MRI (DCE-MRI) parameters have been shown to be biomarkers for treatment response in glioblastoma (GBM). However, variations in analysis and measurement methodology complicate determination of biological changes measured via DCE. The aim of this study is to quantify DCE-MRI variations attributable to analysis methodology and image quality in GBM patients.

Nanoparticle Mediated Gene Therapy: A Trailblazer Armament to Fight CNS Disorders.

Central nervous system (CNS) disorders account for boundless socioeconomic burdens with devastating effects among the population, especially the elderly. The major symptoms of these disorders are neurodegeneration, neuroinflammation, and cognitive dysfunction caused by inherited genetic mutations or by genetic and epigenetic changes due to injury, environmental factors, and disease-related events. Currently available clinical treatments for CNS diseases, i.

Construction of CdSe-AuPd quantum dot 0D/0D hybrid photocatalysts: charge transfer dynamic study with electrochemical analysis for improved photocatalytic activity.

The integration of semiconductor quantum dots and noble metal nanoparticles can efficiently couple numerous effects corresponding to the individual domains of the hybrid system for a variety of applications. Herein, we establish a direct correlation between the electronic band structure and optical band gap of monometallic and bimetallic alloy nanoparticle decorated CdSe quantum dots, which in turn regulate the charge shuttling dynamics in a quantum dot hybrid (QDH) system. Directly coupled Au, Pd, AuPd, and CdSe QDHs were prepared a simple fabrication technique.

Reductively disilylated N-heterocycles as versatile organosilicon reagents.

The reductively disilylated N-heterocyclic systems 1,4-bis(trimethylsilyl)-1-aza-2,5-cyclohexadiene (1Si), 1,4-bis(trimethylsilyl)-1,4-dihydropyrazine (2Si) and its methyl derivatives (3Si and 4Si), and 1,1'-bis(trimethylsilyl)-4,4'-bipyridinylidene (5Si) are proficient organosilicon reagents owing to their low first vertical ionization potentials and the heterophilicity of the polarized N-Si bonds. These have prompted their reactivity as two-electron reductants or reductive silylations. These reactions benefit from the concomitant rearomatization of the N-heterocycles and liberation of trimethylsilyl halides or (MeSi)O, which are mostly volatile or easily removable byproducts.

Λ_{c}^{+} Production and Baryon-to-Meson Ratios in pp and p-Pb Collisions at sqrt[s_{NN}]=5.02 TeV at the LHC.

The prompt production of the charm baryon Λ_{c}^{+} and the Λ_{c}^{+}/D^{0} production ratios were measured at midrapidity with the ALICE detector in pp and p-Pb collisions at sqrt[s_{NN}]=5.02  TeV. These new measurements show a clear decrease of the Λ_{c}^{+}/D^{0} ratio with increasing transverse momentum (p_{T}) in both collision systems in the range 2 View Article and Find Full Text PDF

Meta-analysis of uranium contamination in groundwater of the alluvial plains of Punjab, northwest India: Status, health risk, and hydrogeochemical processes.

Despite numerous studies, there are many knowledge gaps in our understanding of uranium (U) contamination in the alluvial aquifers of Punjab, India. In this study, a large hydrogeochemical dataset was compiled to better understand the major factors controlling the mobility and enrichment of uranium (U) in this groundwater system. The results showed that shallow groundwaters (<60 m) are more contaminated with U than from deeper depths (>60 m).

Temporal exposure to chronic unpredictable stress induces precocious neurobehavioral deficits by distorting neuromorphology and glutathione biosynthesis in zebrafish brain.

Modelling of chronic stress conditions in experimental animals and its neuropsychiatric outcomes has been well documented in literature. Zebrafish (Danio rerio) by exhibiting significant genetic and epidemiological similarities with human beings, has now emerged as a promising animal model of translational research. In this line, risk assessment following exposure to chronic unpredictable stress (CUS) towards neurobehavioral response and neuromorphology of sensitive brain region in zebrafish is the prime objective of the present study.

Hypertension in Young Adults in India: Perspectives and Therapeutic Options amongst Clinician's in a Cross Sectional Observational Study.

Background: The prevalence of hypertension in the young adult population is rising in India. Increased arterial stiffness due to RAAS activation and increased sympathetic overactivity due to stress have been implicated as primary factors for the same. This study was aimed to understand the Indian clinician's perspective on approach to management of hypertension in young adults.

Potential diagnosis of COVID-19 from chest X-ray and CT findings using semi-supervised learning.

COVID-19 is an infectious disease, which has adversely affected public health and the economy across the world. On account of the highly infectious nature of the disease, rapid automated diagnosis of COVID-19 is urgently needed. A few recent findings suggest that chest X-rays and CT scans can be used by machine learning for the diagnosis of COVID-19.

Prevalence of Severe Depression among Adolescents in Rural Area of Odisha, India.

Background: In adolescents, major depression is projected to rank the second most cause of human illness by the year 2022. Unfortunately, half of the depressed adolescents go undiagnosed in primary care settings.

Objectives: The objective is to estimate the prevalence of severe depression among rural adolescents and also to identify few epidemiological determinants causing severe depression.

Quantitative assessment of postural balance in patients with chronic anterior cruciate ligament injury- A controlled study.

Purpose: Evaluation of single and double limb support postural balance in patients with Anterior cruciate ligament (ACL)injury and comparison of the postural strategy adopted after ACL injury/deficiency(ACLD) with that of an age-matched healthy individual.

Methods: The study group that included 33 subjects confirming inclusion criteria had undergone postural balance assessment using the HUMAC Balance system. The parameters of the center of pressure excursion were recorded on a force plate and compared with age, BMI matched 66 healthy volunteers of control group.

Experimental Evidence for an Attractive p-ϕ Interaction.

This Letter presents the first experimental evidence of the attractive strong interaction between a proton and a ϕ meson. The result is obtained from two-particle correlations of combined p-ϕ⊕ p[over ¯]-ϕ pairs measured in high-multiplicity pp collisions at sqrt[s]=13  TeV by the ALICE Collaboration. The spin-averaged scattering length and effective range of the p-ϕ interaction are extracted from the fully corrected correlation function employing the Lednický-Lyuboshits approach.

Evaluation of N doped rGO-ZnO-CoPc(COOH) nanocomposite in cyanide degradation and its bactericidal activities.

In the present study, an attempt has been made to design a solar light driven N-rGO-ZnO- CoPc(COOH) nanocomposite for the degradation of cyanide. The morphological and structural characterization of the synthesized nanocomposite was performed by XRD, FT-IR, XPS, UV-vis DRS, FESEM, TEM, EDS, PL spectra and BET surface area. The results revealed that almost 91% degradation and 86% toxicity removal occurred at 25 mgL of initial cyanide concentration by the N-rGO-ZnO-CoPc(COOH) nanocomposite under illumination of solar light within 120 min.

Investigating immunological interaction between lymphatic filariasis and COVID-19 infection: a preliminary evidence.

The foremost concerns of COVID-19 vaccines are safety and efficacy, which becomes grave in countries with a high burden of Neglected Tropical Diseases. Studies proposed helminthic infections might alleviate the efficacy of COVID-19 vaccines. We share preliminary evidence on the association between filariasis and COVID-19 infection.

Copper mining in the eastern Amazon: an environmental perspective on potentially toxic elements.

Mining activity is of great economic and social importance; however, volumes of metallic ore tailings rich in potentially toxic elements (PTEs) may be produced. In this context, managing this environmental liability and assessing soil quality in areas close to mining activities are fundamental. This study aimed to compare the concentrations of PTEs-arsenic (As), barium (Ba), cadmium (Cd), cobalt (Co), chromium (Cr), copper (Cu), mercury (Hg), molybdenum (Mo), nickel (Ni), lead (Pb) and zinc (Zn)-as well as the fertility and texture of Cu tailings and soils of native, urban and pasture areas surrounding a Cu mining complex in the eastern Amazon.

Chronic bisphenol A exposure induces temporal neurobehavioral transformation and augmented chromatin condensation in the periventricular gray zone of zebrafish brain.

Bisphenol A (BPA) is an industrial synthetic chemical that is extensively used for manufacturing polycarbonate plastics and epoxy resins. However, there is limited literature on BPA-induced temporal neurobehavioral transformation and oxidative stress-mediated neurodegeneration in the subtle region of the zebrafish brain. Consequently, an investigational setup was prepared to study the temporal response to duration-dependent BPA exposure on neurobehavioral, oxidative stress, and neurodegeneration in zebrafish.

Viral characteristics and clinical presentation in dengue co-infection- Findings from a facility based observational study in Odisha, India.

Background: Dengue has affected many countries globally. Two-fifths part of the world is at risk, which can be affected by dengue disease. In India, the dengue incidence has increased in the recent past and emerged as an important health problem in many states including Odisha.

Stable hybrid plasmonic directional coupler based on an embedded silver nanostructure waveguide.

In this paper, a stable hybrid plasmonic optical directional coupler based on an embedded silver nanostructure that can offer a power transfer up to 95% is presented. This optimum power transfer is obtained at an outer edge-to-edge separation of 0.58 µm between the two waveguides.

Intermittent Learning Through Operant Conditioning for Cyber-Physical Systems.

This article presents a novel scheme, namely, an intermittent learning scheme based on Skinner's operant conditioning techniques that approximates the optimal policy while decreasing the usage of the communication buses transferring information. While traditional reinforcement learning schemes continuously evaluate and subsequently improve, every action taken by a specific learning agent based on received reinforcement signals, this form of continuous transmission of reinforcement signals and policy improvement signals can cause overutilization of the system's inherently limited resources. Moreover, the highly complex nature of the operating environment for cyber-physical systems (CPSs) creates a gap for malicious individuals to corrupt the signal transmissions between various components.

Validation of the OPtimal Treatment of Angina (OPTA) Questionnaire in Indian Patients with Chronic Stable Angina.

Background: A rising burden of coronary artery disease (CAD) in India is a major cause of concern, with angina being the leading manifestation. Hence a questionnaire to sensitize the clinicians about stable angina management and to assist in risk stratification is imperative.

Objective: To evaluate the content and face validity of a modified questionnaire adapted from the 7-item Seattle Angina Questionnaire (SAQ).

Development of a Conserved Chimeric Vaccine for Induction of Strong Immune Response against Using Immunoinformatics Approaches.

is one of the most notorious Gram-positive bacteria with a very high mortality rate. The WHO has listed as one of the ESKAPE pathogens requiring urgent research and development efforts to fight against it. Yet there is a major layback in the advancement of effective vaccines against this multidrug-resistant pathogen.

Lipid nanocarrier of selegiline augmented anti-Parkinson's effect via P-gp modulation using quercetin.

In the present study, SEL was loaded in a lipid nanocarrier (LNC) formulation with a P-gp pump inhibitor i.e., Quercetin (QUR) for improving the bioavailability of the SEL in the brain via the oral route.