Detection of Tilapia parvovirus in farm-reared tilapia in India and its isolation using fish cell lines.

Tilapia parvovirus (TiPV) is an emerging viral pathogen and responsible for severe economic loss in tilapia culture production. Lethargic, cutaneous haemorrhages; ocular lesions; discolouration of gill and cloudy eye and exophthalmia are common symptoms of TiPV. The TiPV-suspected tilapia fish were collected from grow-out ponds situated in different parts of Tamil Nadu, India, and screened for TiPV by PCR.

Monitoring CO as a plant signaling molecule under heavy metal stress using carbon nanodots.

Carbon monoxide (CO) is widely recognized as a significant environmental pollutant and is associated with numerous instances of accidental poisoning in humans. However, it also serves a pivotal role as a signaling molecule in plants, exhibiting functions analogous to those of other gaseous signaling molecules, including nitric oxide (NO) and hydrogen sulfide (HS). In plant physiology, CO is synthesized as an integral component of the defense mechanism against oxidative damage, particularly under abiotic stress conditions such as drought, salinity, and exposure to heavy metals.

Withaferin A inhibits Chikungunya virus nsP2 protease and shows antiviral activity in the cell culture and mouse model of virus infection.

Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus causing fever, myalgia, and debilitating joint swelling and pain, which in many patients becomes chronic. The frequent epidemics of CHIKV across the world pose a significant public health burden necessitating the development of effective antiviral therapeutics. A cellular imaging-based high-content screening of natural compounds identified withaferin A (WFA), a steroidal lactone isolated from the plant Withania somnifera, as a potent antiviral against CHIKV.

A comprehensive review of postharvest quality and non-thermal preservation techniques for functional mushrooms.

Health concerns are increasingly prevalent due to aging populations and lifestyle-related diseases. Concurrently, modern consumers seek natural alternatives and are wary of medication side effects, emphasizing the importance of natural compounds for health maintenance. Functional mushrooms, known for their adaptogenic properties, offer health benefits beyond nutrition and are valued as nutraceuticals and functional foods.

Exploring multi-media geochemical relationships in the southeastern Amazonian basin: A way forward to define source and background levels of potentially toxic elements in lake sediments.

Understanding geochemical source-sink relationships is an important aspect for developing background values of potentially toxic elements (PTEs) in a lake basin. This approach was studied in the Araguaia belt of Amazonia, Brazil. A total of 96 sediments (from 13 sediment core, low-altitude lateritic plateaus; LA2-LA14), 36 surface soils, and 19 catchment crusts/rocks were collected in 2022-2023 and chemical analysis of these samples was performed in the fine fraction (<177 μm) using XRF and ICP-MS.

Microbial Diversity and Resistome in Milk of Cows with Subclinical Mastitis in a Coastal District of Odisha, India.

Mastitis is a globally prevalent bacterial disease of lactating cows. Prevention and control of this multi-etiological complex disease relies upon administration of antibiotics. This has led to the emergence of newer multi-drug resistant strains.

Symmetry Breaking in Supramolecular Gel Condensation.

Supramolecular condensation during cooling cycles often transitions through multiple metastable phases before achieving a stable crystalline state. Metastability arises from various competing parameters like symmetrical arrangement, and supramolecular bonding and manifests at different temperatures. Symmetrical physical arrangements can minimize vibrational energy and stabilize the systems at higher temperatures.

Insights into the Solution Processing of Non-van der Waals Boron Carbide.

Exfoliation of non-layered materials is crucial to unleash their enormous potential in wide range of applications. However, the presence of strong non-van der Waals interactions in all three dimensions makes exfoliation challenging. Boron carbide (BC), known for its high hardness, holds great potential for diverse applications.

Synthesis of nitrogen-doped carbon dot/tin disulfide nanosheet composite electro-catalysts for dye-sensitized solar cells.

Nitrogen-doped carbon dots (N-CDs) and vertically-grown tin disulfide (SnS) nanosheets are synthesized via hydrothermal method and chemical vapor deposition technique, respectively. The SnSnanosheets are directly fabricated on flexible carbon cloth (CC), and then their basal planes are decorated with N-CDs. The as-prepared composite electrodes are used as the counter electrode for the application in dye-sensitized solar cells (DSSCs).

USP10 deubiquitinates and stabilizes CD44 leading to enhanced breast cancer cell proliferation, stemness and metastasis.

Despite extensive research, strategies to effectively combat breast cancer stemness and achieve a definitive cure remains elusive. CD44, a well-defined cancer stem cell (CSC) marker is reported to promote breast cancer tumorigenesis, metastasis, and chemoresistance. However, mechanisms leading to its enhanced expression and function is poorly understood.

Electrically Controlled Excitons, Charge Transfer Induced Trions, and Narrowband Emitters in MoSe-WSe Lateral Heterostructure.

Controlling excitons and their transport in two-dimensional (2D) transition metal dichalcogenide heterostructures is central to advancing photonics and electronics on-chip integration. We investigate the controlled generation and manipulation of excitons and their complexes in monolayer MoSe-WSe lateral heterostructures (LHSs). Incorporating graphene as a back gate and edge contact in a field-effect transistor geometry, we achieve the precise electrical tuning of exciton complexes and their transfer across interfaces.

Harnessing machine learning technique to authenticate differentially expressed genes in oral squamous cell carcinoma.

Objective: Advancements in early detection of the disease, prognosis and the development of therapeutic strategies necessitate tumor-specific biomarkers. Despite continuous efforts, no molecular marker has been proven to be an effective therapeutic tool for the early detection of cancer. The study aims to determine diagnostic and prognostic signature genes that may be involved in cancer pathology and hence, may serve as molecular markers.

Apicomplexan Espionage: Orchestrated Miscommunication at the Host-Parasite Interface.

Intracellular parasites, including and , are entirely reliant on the active scavenging of host-derived nutrients to fuel their replicative cycle, as they are confined within a specialized membrane-bound compartment, the parasitophorous vacuole (PV). Initial observations, based on the proximity of host vesicles to the parasitophorous vacuole membrane (PVM), suggested that parasites utilize host vesicles to obtain essential nutrients. However, mounting evidence has now unequivocally demonstrated that intracellular pathogens establish membrane contacts with host organelles, establishing control over host cellular machinery.

Quantification and spatial analysis of gridded (0.1° × 0.1°) emission of indirect GHGs/Air pollutants from anthropogenic sources in India.

Indirect greenhouse gases (GHGs) play a key role in modulating both regional and global atmospheric chemistry and act as air pollutants that degrade air quality. The rising number of premature deaths and notable health hazards could be linked to increasing concentration of these air pollutants in the atmosphere. As a developing nation, India is often regarded as one of the most polluting countries due to increasing anthropogenic activities.

Deletion of both anaerobic regulator genes fnr and narL compromises the colonization of Salmonella Typhimurium in mice model.

Salmonella Typhimurium (STM), a zoonotic pathogen, can adjust its metabolic pathway according to the variations in the partial pressure of atmospheric oxygen and nitrate via fumarate nitrate reductase regulator (Fnr) and NarL, the response regulator for nitrate reductase. Both Fnr and NarL have been individually reported to be the contributors of virulent phenotypes of STM. Hypoxia along with nitrate-rich environment are prevalent in macrophages and the Salmonella-induced inflammatory lumen of the host's large intestine activates both fnr and narL genes.

Revealing the Role of Electronic Effect to Modulate the Photophysics and Z-Scan Responses of -Locked GFP Chromophores.

Three novel core green fluorescent protein (GFP) chromophore analogues, based on a doubly locked conformation and variable electronic effects by replacing one hydrogen with bromine, iodine, and methyl, respectively, have been synthesized to modulate the push-pull effect. These chromophores exhibited intramolecular H-bonding, as evidenced by single-crystal X-ray and H NMR studies. The fluorescence quantum yields (ϕ) of all of the chromophores were found to be more than an order of magnitude higher (∼0.

Harnessing bacterial metabolites for enhanced cancer chemotherapy: unveiling unique therapeutic potentials.

Cancer poses a serious threat to health globally, with millions diagnosed every year. According to Global Cancer Statistics 2024, about 20 million new cases were reported in 2022, and 9.7 million people worldwide died of this condition.

Bisphenol F-induced precocious genesis of aggressive neurobehavioral response is associated with heightened monoamine oxidase activity and neurodegeneration in zebrafish brain.

The production and use of plastics and plastics products has increased dramatically in recent decades. Moreover, their unprotected disposal into ambient life sustaining environment poses a significant health risk. Bisphenol F (BPF) an alternative to bisphenol A (BPA) has been extensively employed for making of plastics.

Palmitoleate protects against lipopolysaccharide-induced inflammation and inflammasome activity.

Inflammation is part of natural immune defense mechanism against any form of infection or injury. However, prolonged inflammation could perturb cell homeostasis and contribute to the development of metabolic and inflammatory diseases, including maternal obesity, diabetes, cardiovascular diseases, and metabolic dysfunction-associated steatotic liver diseases (MASLD). Polyunsaturated fatty acids have been shown to mitigate inflammatory response by generating specialized proresolving lipid mediators, which take part in resolution of inflammation.

Does Adopting Western Low-density Lipoprotein Cholesterol Targets Expose Indians to a Higher Risk of Cardiovascular Events? Expert Opinion From the Lipid Association of India.

Adverse cardiovascular (CV) events have declined in Western countries due at least in part to aggressive risk factor control, including dyslipidemia management. The American and European (Western) dyslipidemia treatment guidelines have contributed significantly to the reduction in atherosclerotic cardiovascular disease (ASCVD) incidence in the respective populations. However, their direct extrapolation to Indian patients does not seem appropriate for the reasons described below.

Clinical profile and outcomes in Tolosa-Hunt Syndrome; a systematic review.

Introduction: Tolosa-Hunt Syndrome (THS) stands as a rare headache disorder distinguished by painful ophthalmoplegia, accompanied by headaches and cranial nerve palsies. The syndrome was initially identified by Eduardo Tolosa in Spain in 1954. He observed granulomatous inflammation surrounding a carotid siphon in a patient with an intracavernous carotid aneurysm.