Hybrid Therapy versus Sequential Therapy for Eradication of : A Randomized Controlled Trial.

Objective: To compare the sequential therapy (ST) with the hybrid therapy (HT) for the eradication of .

Materials And Methods: Patients with peptic ulcer disease and gastritis found to be positive were randomized to HT group who received omeprazole (20 mg bid) and amoxicillin (1 g bid) for 7 days followed by omeprazole (20 mg bid), amoxicillin (1 g bid), clarithromycin (500 mg bid), and metronidazole (400 mg tid) for the next 7 days and ST group who received omeprazole and amoxicillin for 5 days followed by omeprazole, clarithromycin, and metronidazole for the next 5 days. Eradication rate, compliance, and complications were compared.