Publications by authors named "Saho Wada"
Background: In the Fourth Basic Plan to Promote Cancer Control Programs, the number of medical practices using claims data from the National Database (NDB) is measured as a clinical indicator. This study aimed to clarify the characteristics of patients who received care as an indicator of medical practices using more manageable claims data.
Methods: We used the claims data collected by the DeSC Healthcare, Inc.
Article Synopsis
- Cefepime, a fourth-generation antibiotic, can cause neurotoxic side effects like encephalopathy, particularly in patients with compromised blood-brain barriers (BBB) and renal issues.
- A case study of a 79-year-old woman with depression and cancer demonstrated that after receiving cefepime, she developed confusion and other neurological symptoms without apparent brain damage or kidney dysfunction.
- The case suggests that depression and cancer may increase the risk of cefepime-induced encephalopathy, highlighting the need for doctors to monitor such patients closely to avoid misdiagnosis and ensure proper treatment.
Background: Benzodiazepines are known for their possible risk of delirium, especially when administered to older adults or during the perioperative period. However, the risk of sudden discontinuation of benzodiazepines and subsequent withdrawal delirium seems to be underappreciated and not properly recognized in cancer treatment, even among healthcare workers.
Case Presentation: A man in his late 70s was diagnosed with rectal cancer and had a history of taking etizolam and alprazolam for over 15 years.
Aim: Behavioral psychological symptoms of dementia (BPSD) are sometimes difficult to treat due to severe psychiatric symptoms such as delusions of poisoning and violent behavior. Moreover, in cases of parental neglect, the management of these psychiatric symptoms becomes more difficult. Therefore, home-visiting doctors sometimes have to manage patients with BPSD and severe psychiatric symptoms, and a new approach is needed.
View Article and Find Full Text PDFObjectives: There is concern that hydroxyzine exacerbates delirium, but a recent preliminary study suggested that the combination of haloperidol and hydroxyzine was effective against delirium. This study examined whether the concomitant use of hydroxyzine and haloperidol worsened delirium in patients with cancer.
Methods: This retrospective, observational study was conducted at 2 general hospitals in Japan.
Background: Phenotyping analysis that includes time course is useful for understanding the mechanisms and clinical management of postoperative delirium. However, postoperative delirium has not been fully phenotyped. Hypothesis-free categorization of heterogeneous symptoms may be useful for understanding the mechanisms underlying delirium, although evidence is currently lacking.
View Article and Find Full Text PDFArticle Synopsis
- The Japanese Psycho-Oncology Society and the Japanese Association of Supportive Care in Cancer have updated guidelines for managing delirium in adult cancer patients, detailing the development process and key recommendations.
- A multidisciplinary group formulated new clinical questions on non-drug interventions and drug treatments like antipsychotics and trazodone, along with a review of existing questions.
- The guidelines aim to enhance the prevention, assessment, and management of delirium in cancer patients in Japan.
Objective: Preventing postoperative delirium with agitation is vital in the older population. We examined the preventive effect of yokukansan on postoperative delirium with agitation in older adult patients undergoing highly invasive cancer resection.
Methods: We performed a secondary per-protocol analysis of 149 patients' data from a previous clinical trial.
Delirium occurs very frequently in cancer patients. Insomnia is a symptom of delirium. Lemborexant is a drug that regulates sleep-wake rhythms without causing extrapyramidal symptoms.
View Article and Find Full Text PDFContext: No standard preventive or therapeutic methods have been established for preoperative anxiety and postoperative delirium in patients with cancer.
Objectives: To clarify the therapeutic effect of yokukansan for perioperative psychiatric symptoms in patients with cancer as well as to confirm its safety profile.
Methods: This is a randomized, double-blind, and placebo-controlled trial conducted at a single center in Tokyo, Japan.
Article Synopsis
- - The Japanese Psycho-Oncology Society and the Japanese Association of Supportive Care in Cancer created new guidelines for managing delirium in adult cancer patients to improve clinical assessment and treatment practices.
- - The guidelines were developed through a systematic review process involving a multidisciplinary team and independent reviews of literature up to May 2016, using a recognized grading system to assess evidence and recommendations.
- - The article summarizes the recommendations and their rationales, emphasizing the need for further clinical research to enhance delirium management in cancer patients.
Background: Optimal cancer survivorship care needs its comprehensive guidelines. We aimed to identify English and Japanese guidelines that include cancer survivorship in their title, the issues highlighted in such guidelines, and any existing oncology practice guidelines in Japan that address these issues.
Methods: This literature review was performed in three stages.
Importance: Although several pharmacological interventions for delirium have been investigated, their overall benefit and safety remain unclear.
Objective: To evaluate evidence regarding pharmacological interventions for delirium treatment and prevention.
Data Sources: PubMed, Embase, ProQuest, ScienceDirect, Cochrane Central, Web of Science, ClinicalKey, and ClinicalTrials.
Background: Preoperative anxiety and postoperative delirium affect both short- and long-term prognoses in patients with cancer; therefore, these conditions require early prevention and treatment. However, no standard preventive or therapeutic methods have been established for them. Yokukansan, a Japanese herbal medicine for the treatment of insomnia and anxiety, causes relatively few adverse drug reactions and effectively improves the behavioral and psychological symptoms of dementia.
View Article and Find Full Text PDFBackground: Postoperative delirium is a common and important complication in cancer patients. We need to identify patients at high risk of postoperative delirium such that it can be prevented preoperatively or in early postoperative phase. The aim of this study was to investigate whether preoperative anxiety predicted onset of postoperative delirium in cancer patients, not only in order to identify high-risk groups but also to help develop new preventive approaches.
View Article and Find Full Text PDFBackground: Yokukansan (YKS), a Japanese traditional herbal medicine for neurosis and insomnia, is speculated to be useful for perioperative psychiatric symptoms in cancer patients, but there exists little empirical evidence. This study provides preliminary data about the efficacy, feasibility, and side effects of YKS for the treatment of preoperative anxiety and postoperative delirium in cancer patients.
Methods: We retrospectively reviewed the medical records of colorectal cancer patients who took YKS for preoperative anxiety, evaluating the following: (1) patient characteristics, (2) feasibility of taking YKS, (3) changes in preoperative anxiety based on the Clinical Global Impression (CGI) scale and Edmonton Symptom Assessment System-revised (ESAS-r-anxiety), (4) incidence of postoperative delirium and (5) YKS-related side effects.
Purpose: The aim of this study is to describe physicians' clinical practice of discussing fertility issues with cancer patients and determine the factors associated with such discussion.
Methods: In this cross-sectional study, a nationwide Internet survey was conducted among physicians who provided daily medical care to cancer patients at hospitals or clinics. Participants answered a questionnaire assessing characteristics, discussion practices, attitudes, and barriers regarding fertility preservation.
Context: There is controversy around the association between depressive symptoms and age in adult cancer patients.
Objectives: The aim of this study was to evaluate the following hypotheses: 1) cancer patients' depressive symptoms decrease with age, and 2) in individuals aged 65 years or older, depressive symptoms increase because of the effect of somatic symptoms.
Methods: We retrospectively analyzed a database of 356 cancer patients who were consecutively recruited in a previous multicenter cross-sectional study.
Myxofibrosarcoma (MFS) has a spectrum of malignant fibroblastic lesions with variably myxoid stroma and pleomorphism. A 67-year-old man with a bulky mass on his chest wall was diagnosed with MFS. He underwent F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography for detection of metastasis.
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