Predictors of Drug Retention and Survival Rate of bDMARDs in Rheumatoid Arthritis: A Four-Year Real-Life Tunisian Experience.

Introduction: This study aims to investigate the efficacy and tolerance of biologic disease-modifying anti-rheumatic drug (bDMARDs) in the current management of rheumatoid arthritis (RA) by identifying the retention time and survival rate of bDMARDs.

Materials And Methods: We conducted a retrospective cohort study including Tunisian patients initiating bDMARD treatment between 2016 and 2018 whose data were collected from the National Health Insurance Fund (NHIF). The NHIF is the national office which organises and centralises patients under bDMARDs from all over the country.

Generative AI unlocks PET insights: brain amyloid dynamics and quantification.

Introduction: Studying the spatiotemporal patterns of amyloid accumulation in the brain over time is crucial in understanding Alzheimer's disease (AD). Positron Emission Tomography (PET) imaging plays a pivotal role because it allows for the visualization and quantification of abnormal amyloid beta (Aβ) load in the living brain, providing a powerful tool for tracking disease progression and evaluating the efficacy of anti-amyloid therapies. Generative artificial intelligence (AI) can learn complex data distributions and generate realistic synthetic images.

The STOIC2021 COVID-19 AI challenge: Applying reusable training methodologies to private data.

Challenges drive the state-of-the-art of automated medical image analysis. The quantity of public training data that they provide can limit the performance of their solutions. Public access to the training methodology for these solutions remains absent.

Effects of coach-delivered verbal encouragement on the physiological and psychological responses of adolescent players in small-sided basketball games.

Introduction: The confluence of physiological and psychological dynamics is fundamental to athletic performance, particularly in basketball, where physical skill and mental resilience are imperative. While the role of verbal encouragement (VE) as a catalyst for enhancing performance has been explored in various sports disciplines, its specific effects within the basketball have not been adequately examined. Addressing this gap, the current study zeroes in on the influence of coach-delivered VE on the physiological and psychological responses of adolescent basketball players engaged in small-sided games (SSG), providing a focused analysis of how directed encouragement can modulate performance and experience in young athletes.

Combined Effects of Listening to Preferred Music and Video Feedback, during Warm-Up, on Physical Performance in Young Kickboxers.

Although studies have indicated that the prior use of video feedback and music listening separately improves physical performance and positive feelings in various sports, to our knowledge, no studies have investigated their combined effect in combat-sports-specific tasks. The aim of this study was to determine the combined effect of listening to preferred music and video feedback on aerobic and anaerobic performance in male kickboxers. In a counterbalanced crossover study design, twenty kickboxers underwent three kicking exercises under one of three conditions: (1) control condition, (2) combined listening to preferred music and video feedback, and (3) video feedback during 10-min of rope warm-up.

Enhancing Skills, Mood, and Performance in Overweight Handball Players: Exploring Individual vs. Collective Verbal Encouragement Strategies.

This comparative study investigates the effectiveness of two teaching methods, individual verbal encouragement and collective verbal encouragement, in enhancing the technical-tactical skills and mood state of obese students during handball matches. This study employs a randomized controlled design and involves 28 overweight students (50% females), age: 17.4 ± 2.

Effect of Verbal Encouragement on Performance and Affective Responses in Male Sport Science Students during Sprint Modalities.

This investigation aimed to examine the effect of verbal encouragement teacher to student (VETS) versus verbal encouragement student to student (VESS) on physical performance and affective responses during different modalities of sprint tests in active male students. In a randomized crossover design, twenty-two male sport science students (age: 21 ± 1.2 years, body height: 1.

Causality-driven multivariate stock movement forecasting.

Our study aims to investigate the interdependence between international stock markets and sentiments from financial news in stock forecasting. We adopt the Temporal Fusion Transformers (TFT) to incorporate intra and inter-market correlations and the interaction between the information flow, i.e.

Peer Verbal Encouragement Is More Effective than Coach Encouragement in Enhancing CrossFit-Specific 1-RM Strength, Functional Endurance, and Psychophysiological Assessment Performance.

This study compares the effects of coach verbal encouragement (CVE) and peer verbal encouragement (PVE) on CrossFit-specific one-repetition maximum (1-RM) strength, functional endurance, and psychophysiological assessments. A total of 36 sports science students (18 males, 18 females; mean age: 21.3 ± 0.

A new CO refrigeration system with two-phase ejector and parallel compression for supermarkets.

This study explores the integration of parallel compression and a two-phase ejector in transcritical CO refrigeration systems, aiming to improve efficiency and performance. This innovative approach bridges the gap between conventional approaches and explores new energy-saving potential. The study uses thermodynamic modeling, mathematical simulation, and in-depth analysis to look at energy and exergy performance in a new configuration for applications in the retail sector at medium evaporation temperatures.

Long-Term Regional Influenza-Like-Illness Forecasting Using Exogenous Data.

Disease forecasting is a longstanding problem for the research community, which aims at informing and improving decisions with the best available evidence. Specifically, the interest in respiratory disease forecasting has dramatically increased since the beginning of the coronavirus pandemic, rendering the accurate prediction of influenza-like-illness (ILI) a critical task. Although methods for short-term ILI forecasting and nowcasting have achieved good accuracy, their performance worsens at long-term ILI forecasts.

Semi-supervised medical image classification via distance correlation minimization and graph attention regularization.

We propose a novel semi-supervised learning method to leverage unlabeled data alongside minimal annotated data and improve medical imaging classification performance in realistic scenarios with limited labeling budgets to afford data annotations. Our method introduces distance correlation to minimize correlations between feature representations from different views of the same image encoded with non-coupled deep neural networks architectures. In addition, it incorporates a data-driven graph-attention based regularization strategy to model affinities among images within the unlabeled data by exploiting their inherent relational information in the feature space.

Diverticulosis and risk of diverticulitis in 10 years; a Swedish retrospective observational study.

Background: Diverticulosis is a common condition and is thought to be increasing in the Western population. Several studies have attempted to estimate the prevalence of diverticulosis and it's inflamed state, diverticulitis, with results varying depending on study population and methodology, The aim of this study was to investigate the prevalence of diverticulosis in patients undergoing colonoscopy at a Swedish academic referral centre and to study the incidence of diverticulitis in a 10-year follow-up.

Methods: All patients who had undergone colonoscopy at the Endoscopy unit, Skåne University Hospital, Sweden, during 01 January 2010 through 31 December 2011 were identified.

Rayleigh-based segmentation of ISAR images.

Inverse synthetic aperture radar (ISAR) provides a solution to increase the radar angular resolution by observing a moving target over time. The high-resolution ISAR image should undergo a segmentation step to get the target's point cloud data, which is then used for classification purposes. Existing segmentation algorithms seek an optimal threshold in an iterative manner, which adds to the complexity of ISAR and results in an increase in the processing time.

Focal Segmental Glomerulosclerosis and Hyalinosis in a Patient with Spondyloarthritis: A Rare Renal Involvement Case Report.

Background: During its course, spondyloarthritis (SpA) may be associated with extra-articular manifestations affecting several organs. Renal involvement is one of the most common extra-articular manifestations and is dominated by secondary amyloidosis (AA), immunoglobulin A (IgA) nephropathy, and urolithiasis. Other nephropathies such as Focal segmental glomerulosclerosis and hyalinosis (FSGS) are less common and are limited to few case reports.

Spinal Tuberculosis: Features and Early Predictive Factors of Poor Outcomes.

Introduction: Tuberculosis is still endemic in Tunisia. Among musculoskeletal involvement, spinal tuberculosis (STB) or «Pott's Disease» is the most common and can lead to serious neurological complications. The purpose of our study was to focus on STB features (clinical, biological, and radiological) and to identify factors associated with early unfavorable outcomes.

Impact of previous diverticulitis on 5-year survival and recurrence rates in patients with colorectal cancer.

Background: Diverticulitis and colorectal cancer (CRC) share epidemiological characteristics, but their relationship remains unknown. It is unclear if prognosis following CRC differ for patients with previous diverticulitis compared to those with sporadic cases and patients with inflammatory bowel disease or hereditary syndromes.

Aim: The aim was to determine 5-year survival and recurrence after colorectal cancer in patients with previous diverticulitis, inflammatory bowel disease and hereditary colorectal cancer compared to sporadic cases.

Peer Verbal Encouragement Enhances Offensive Performance Indicators in Handball Small-Sided Games.

Objective: This study aimed at assessing the effects of two verbal encouragement modalities on the different offensive and defensive performance indicators in handball small-sided games practiced in physical education settings.

Methods: A total of 14 untrained secondary school male students, aged 17 to 18, took part in a three-session practical intervention. Students were divided into two teams of seven players (four field players, a goalkeeper, and two substitutes).

Beyond shallow feelings of complex affect: Non-motor correlates of subjective emotional experience in Parkinson's disease.

Affective disorders in Parkinson's disease (PD) concern several components of emotion. However, research on subjective feeling in PD is scarce and has produced overall varying results. Therefore, in this study, we aimed to evaluate the subjective emotional experience and its relationship with autonomic symptoms and other non-motor features in PD patients.

A multidimensional ODE-based model of Alzheimer's disease progression.

Data-driven Alzheimer's disease (AD) progression models are useful for clinical prediction, disease mechanism understanding, and clinical trial design. Most dynamic models were inspired by the amyloid cascade hypothesis and described AD progression as a linear chain of pathological events. However, the heterogeneity observed in healthy and sporadic AD populations challenged the amyloid hypothesis, and there is a need for more flexible dynamical models that accompany this conceptual shift.

Strong evidence for positive and negative correlational selection revealed by recreating ancestral variation.

The study of adaptation helps explain biodiversity and predict future evolution. Yet the process of adaptation can be difficult to observe due to limited phenotypic variation in contemporary populations. Furthermore, the scarcity of male fitness estimates has made it difficult to both understand adaptation and evaluate sexual conflict hypotheses.