Publications by authors named "Sahil Lala"
Article Synopsis
- Malaria, mainly caused by Plasmodium protozoans, is a significant global health crisis, particularly in Africa, with rising antimalarial drug resistance prompting the need for new treatments.
- Researchers designed and synthesized a new class of compounds (8a-r) showing promising in vitro activity against the chloroquine-sensitive strain of Plasmodium falciparum, with two compounds (8o and 8l) demonstrating the best efficacy and safety profiles.
- The study also explored the binding affinities of these compounds to essential heat shock proteins in the parasite, suggesting potential targets for combating drug resistance.
Malaria is still a complex and lethal parasitic infectious disease, despite the availability of effective antimalarial drugs. Resistance of malaria parasites to current treatments necessitates new antimalarials targeting proteins. The present study reported the design and synthesis of a series of a 2-(4-substituted piperazin-1-yl)--(5-((naphthalen-2-yloxy)methyl)-1,3,4-thiadiazol-2-yl)acetamide hybrids for the inhibition of dihydrofolate reductase (DHFR) using computational biology tools followed by chemical synthesis, structural characterization, and functional analysis.
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