Publications by authors named "Sahil Agrawal"

Article Synopsis
  • A study was conducted on 30 patients with congenital severe ptosis to compare two techniques for silicone rod fixation in frontalis suspension surgery: the novel tarsal tunnel technique and the conventional suture fixation technique.
  • Both techniques resulted in similar postoperative outcomes in terms of eyelid position and patient satisfaction, with no significant complications reported.
  • The tarsal tunnel fixation method showed promising cosmetic and functional results, but further long-term studies are necessary to confirm the effectiveness of this new technique.
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  • A significant increase in cases of sino-orbital mucormycosis (SOM) was observed during the COVID-19 pandemic, leading to a need for effective treatment options beyond traditional orbital exenteration.
  • A study comparing the use of intraorbital injections with Amphotericin B (IOAB) showed that most patients (88.5%) had stable orbital disease after treatment, with minimal deterioration in visual acuity.
  • The findings suggest that IOAB may improve outcomes for patients with mild to moderate SOM, as only a small percentage experienced relapse, highlighting its potential as a globe-conserving therapy.
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Purpose: The coronavirus disease 2019 (COVID-19) pandemic led to overall interrupted medical care, resulting in disease progression and morbidity. The study aimed to evaluate clinicopathological presentations and severity of eyelid malignancy during the COVID era, comparing the results with patients presented during pre-COVID era and evaluating the reasons for delayed presentation in patients with advanced eyelid malignancy in the COVID-era.

Methods: This was a comparative, ambispective observational study.

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  • Organoid nevus syndrome is a rare neurocutaneous condition characterized by sebaceous nevus, seizures, and associated ocular abnormalities.
  • A study involving 13 patients showed that all had sebaceous nevus, with some also experiencing alopecia, seizures, and arachnoid cysts.
  • The main eye-related issues identified were complex choristoma, scleral coat calcification, and upper eyelid coloboma.
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  • Nasal natural killer/T-cell lymphoma (NK/TCL) is a rare type of non-Hodgkin lymphoma that can sometimes affect the orbit, leading to diverse symptoms.
  • A 40-year-old male presented with eyelid swelling and reduced vision, and an initial diagnosis of orbital cellulitis with pansinusitis was made after clinical assessments and imaging.
  • Following surgery and chemotherapy, the patient experienced complete resolution of the mass, with no signs of recurrence after 10 months of follow-up.
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  • The study investigates the effectiveness of sodium chloride (NaCl) 5% drops versus 6% ointment for treating corneal edema caused by conditions like Bullous keratopathy and Fuchs endothelial dystrophy.
  • It involved 40 patients, alternating between the two treatments over a two-week period, measuring outcomes like central corneal thickness and tear osmolarity.
  • Results showed that while the 6% ointment was more effective in reducing corneal thickness and improving tear osmolarity, some patients experienced more side effects, making the 5% drops an alternative for those intolerant to ointments.
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Introduction: We aim to share the experience of a single center in the management of eight cases of renal primitive neuroectodermal tumor (PNET) which are uncommon, aggressive tumors. The objectives were to study the presentation of the disease, the treatment offered and its outcomes, and the comparison of the treatment with published literature.

Methods: The single-center renal PNET data of all patients were retrospectively reviewed from 2011 to 2022.

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Purpose: Retinoblastoma (RB) is the most common intraocular tumor in pediatric age group. The role of genetics has been explored in predicting survival prognosis, but its role in predicting globe salvage remains largely unexplored. We hereby aim to isolate cell-free DNA (cfDNA) from aqueous humor (AH) in RB eyes and validate its use for genetic studies.

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  • This study aimed to analyze the reasons for orbital exenteration, the demographics of patients undergoing the procedure, and how these findings compare to past research over 20 years at a tertiary eye care center.
  • Researchers evaluated 352 cases, revealing that most patients were middle-aged and that eyelid malignancy, specifically squamous cell carcinoma (SCC), was the primary reason for exenteration.
  • The study found an increase in the absolute number of exenterations but a decrease in the ratio compared to other tumor-related surgeries, highlighting changing trends in clinical practice and patient demographics.
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The purpose was to do a study to compare infectious complications in patients operated for MiniPerc or Minimally invasive Percutaneous Nephrolithotomy (MPCNL) using MIP and MPCNL with suction using Shah Superperc sheath for medium-sized renal stones less than 3 cm in size. The primary objective of this study is to compare the infectious complications and the secondary objectives are to compare stone-free rates, complication rates and operative times. A prospective randomized controlled trial with patients having proximal ureteral and renal stones of 10-30 mm size and planned for MPCNL done at a single institute.

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Purpose: To excise external angular dermoid cyst (EADC) by transconjunctival approach and compare the surgical outcomes with the standard transcutaneous approach.

Design: This was a prospective, pilot, interventional, comparative study.

Methods: Patients with EADC with no or minimal fixity to the underlying bone on palpation and limited to eyelid were recruited.

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Objective: End-stage ocular diseases usually end up with atrophic bulbi or phthisis bulbi leading to orbital volume loss which needs to be addressed. We studied the use of autologous fat for volume augmentation of the orbit because it is minimally invasive and allows early rehabilitation with the use of an artificial eye.

Design: It was a prospective, interventional study.

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Neuroendocrine neoplasms are derived from the epithelial lineages mainly of respiratory tract, with predominant neuroendocrine differentiation. There are only a handful of documented cases of paranasal small cell neuroendocrine carcinomas (SNEC) with primary orbital involvement. Here, the authors describe a 33-year-old male patient with rapidly progressive swelling of the right lower lid with proptosis since 4 weeks.

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Background: Cicatricial ectropion can be corrected by invasive surgical modalities such as full-thickness skin graft, lateral tarsal strip procedure, etc., which are associated with donor site morbidity and additional scars. Use of autologous fat graft (AFG) in treatment of burn scars has previously shown encouraging clinical results as to skin color, texture, and softness.

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Purpose: The aim of this study was to analyze the presence of the SARS-CoV-2 virus in the corneal tissue of asymptomatic deceased novel coronavirus disease 2019 (COVID-19) patients.

Methods: This was a cross-sectional study performed at a tertiary eye hospital. All corneas of the deceased asymptomatic donors who tested positive for SARS-CoV-2 on a nasopharyngeal swab at the time of corneal tissue harvesting were included in the study.

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Clinical Relevance: Patients undergoing exenteration have significant anxiety and depression, and lower quality of life that worsens after surgery. Therefore, counselling by an eye health-care provider along with the team of psychologist and psychiatrist could be provided pre-operatively to assess baseline psychosocial status and be continued post-operatively to look for any deterioration.

Background: Orbital exenteration comes with psychological trauma of disfigurement of face.

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Purpose: Fraser syndrome is a rare congenital disorder comprising cryptophthalmos, syndactyly, and many times, urogenital anomalies. Herein, the authors aimed to study and report the clinical features and orbital anomalies in cases diagnosed with Fraser syndrome.

Methods: The authors retrospectively evaluated the records of patients with Fraser syndrome who had presented to a tertiary eye care hospital in northern India in the last 2 years (from January 2019 to December 2020).

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Article Synopsis
  • The Tessier classification categorizes congenital facial cleft disorders based on their anatomical features and is relevant for understanding associated ocular and orbital issues.* -
  • A study was conducted on 40 patients with Tessier clefts at a tertiary care eye hospital in northern India, revealing that most cases involved pediatric males, with unilateral clefts and various ocular anomalies being common.* -
  • The findings underscore the importance of Tessier classification for recognizing and managing associated ocular defects, as well as its connections to syndromes like Goldenhar and Fraser.*
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Objectives: To study the thickness of levator palpebra superioris-Muller's muscle complex (LMC) on ultrasound biomicroscopy (UBM) and to correlate with the clinical response to botulinum toxin A (BTA) injection in patients with inactive-stage of thyroid-related upper eyelid retraction (UER). We also studied the correlation of clinical parameters, preinjection with postinjection values.

Methods: This was a prospective, interventional study.

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