Publications by authors named "Sahika Cıngır"
Recent studies have demonstrated that repeated short-term nutrient withdrawal (i.e. fasting) has pleiotropic actions to promote organismal health and longevity.
View Article and Find Full Text PDFTransformed cancer cells have an altered metabolism, characterized by a shift towards aerobic glycolysis, referred to as 'the Warburg phenotype'. A change in flux through mitochondrial OXPHOS and cytosolic pathways for ATP production and a gain of capacity for biomass production in order to sustain the needs for altered growth and morphodynamics are typically involved in this global rewiring of cancer cell metabolism. Characteristically, these changes in metabolism are accompanied by enhanced uptake of nutrients like glucose and glutamine.
View Article and Find Full Text PDFChanges in expression profiles of antioxidant enzymes in diabetic rat kidneys.
Diabetes Metab Res Rev
March 2012
Article Synopsis
- Diabetes leads to oxidative stress due to high glucose levels, causing tissue damage that antioxidants help to protect against.
- In experiments with diabetic rats, the activity of certain antioxidant enzymes like catalase and glutathione peroxidase decreased, despite increased mRNA levels, whereas superoxide dismutase (SOD) activity remained unchanged.
- Treatment with α-lipoic acid and vitamin C boosted the activity of catalase and SOD, and α-lipoic acid also helped restore glutathione levels, highlighting the role of post-translational regulation of antioxidants in combating diabetes-related oxidative stress.