A challenge with 5 cmH2O of positive end-expiratory pressure predicts fluid responsiveness in neurosurgery patients with protective ventilation: an observational study.

Background: Positive end-expiratory pressure (PEEP) increment induces a decrease in Stroke Volume Index (SVI). We hypothesized that the magnitude of SVI reduction due to a 5 cmH2O increase in PEEP could predict fluid responsiveness during low tidal volume ventilation.

Methods: Forty-eight patients completed the study.