Publications by authors named "Sahender Guelbin Aygencel"
Article Synopsis
- This study investigates the link between sepsis-induced acute kidney injury (AKI) and worse outcomes in patients in the intensive care unit (ICU), focusing on identifying risk factors for new-onset AKI among septic patients who initially had no kidney issues.
- Conducted at Gazi University Hospital, the research involved analyzing data from septic patients aged 18 and older, looking at demographics and clinical factors to determine predictors of AKI development and mortality rates.
- Results showed a significant incidence of new-onset AKI (36%), particularly linked to factors like invasive mechanical ventilation, new-onset shock, and higher APACHE-II scores, all of which correlated with longer ICU stays and increased mortality risk.*
Objective: This study aimed to investigate the relationship between procalcitonin (PCT) kinetic and estimated glomerular filtration rates (eGFR) in critically ill patients who had Gram-negative primary bloodstream infection (GN-BSI) and responded to the antimicrobial therapy.
Materials And Methods: This single-centered study was retrospective and observational. Critically ill GN-BSI patients over 18 years old who had clinical and microbiological responses to antibiotic treatment were included in the study.
Background: The coexistence of sepsis and hematological malignancies increases patient vulnerability, revealing the need for precise prognostic markers. This study explores the prognostic significance of lactate levels and clearance in septic patients with hematological malignancies.
Materials And Methods: A retrospective cohort study from January 2016 to December 2019 in a tertiary hematological intensive care unit (ICU) included 167 adults with hematological malignancies and sepsis.
Article Synopsis
- Critically ill cirrhotic patients face a high mortality risk from acute-on-chronic liver failure, and while traditional scoring systems like MELD and Child-Pugh provide some insight, they have limitations that need addressing.* -
- A study involving 175 of these patients showed that the lactate/albumin ratio (LAR) could be a useful prognostic tool, comparable to established scores, with higher ratios linked to increased ICU mortality.* -
- The findings suggest that LAR, alongside the SOFA score assessed at 48 hours, could help predict outcomes and inform treatment strategies, paving the way for further research to validate these results.*
Aim: critical illness often leads to malnutrition and diaphragmatic dysfunction (DD), common in intensive care units (ICU). Ultrasonography (US) is a potent tool for detecting DD. This study examines the connection between malnutrition risk and DD in ICU patients using ultrasonographic diaphragm measurements in medical ICU patients.
View Article and Find Full Text PDFObjective: A 1-day point prevalence study was planned to obtain country data by determining the clinical characteristics, follow-up and treatment methods of coronavirus disease 2019 (COVID-19) cases that required intensive care unit (ICU) treatment in the second year of the pandemic.
Material And Methods: All patients who were hospitalized in the ICUs due to COVID-19 between March 11, 2022, 08.00 am, and March 12, 2022, 08.
Background/aim: The aim of the study was to investigate whether treating haematological malignancy (HM) patients in a separate intensive care unit (ICU) would reduce ICU mortality.
Materials And Methods: HM patients treated by the same ICU team in a general medical ICU (GM-ICU) and a separate haematology ICU (H-ICU) were included in this study. Patients’ demographic characteristics and ICU data were recorded retrospectively.
Article Synopsis
- The study aimed to analyze the characteristics and outcomes of hematopoietic stem cell transplant (HSCT) patients admitted to the Hematology ICU due to infections from 2014 to 2017.
- Out of 62 patients, the major reasons for ICU admission included sepsis and acute respiratory failure, with a high overall mortality rate of 45.2%, primarily influenced by APACHE II scores.
- The research found that both pre-existing and new infections played a significant role in ICU morbidity and mortality, with pneumonia being the most common new infection and no significant differences in outcomes between autologous and allogeneic HSCT patients.
In this study, we investigated placement rate, complication rate and time spent of successful post-pyloric enteral feeding (PPEF) tube insertion procedure guided by ultrasonography (USG). The patients who required enteral nutrition and who admitted to medical intensive care unit (MICU) of Gazi University Hospital were included to this single-center, prospective, cohort study. It was aimed to insert the enteral feeding tube into the proximal duodenum as the post-pyloric area by ultrasonography guidance.
View Article and Find Full Text PDFAngiotensin-converting enzyme (ACE)/Angiotensin (Ang) II pathway has crucial regulatory effects on circulatory hemostasis and immune responses. This pathway has a major role in the development of acute lung injury and acute respiratory distress syndrome (ARDS), which is a devastating complication of SARS-CoV-2 infection. The aim of this study is to investigate the serum ACE activity and its correlation with clinical features and the disease severity in patients with COVID-19.
View Article and Find Full Text PDFBackground: Influenza can cause severe acute respiratory illness (SARI), which occurs as local outbreaks or seasonal epidemics with high intensive care unit (ICU) admission and mortality rates. Mortality is mainly due to SARI.
Objective: The aim of this study was to evaluate the outcome of patients admitted to ICU due to influenza-related SARI in 2017-2018 flu season in Turkey.
Background: The effectual immune response is crucial to defeat viral infections. However, exuberant immune response with features of macrophage activation syndrome (MAS) lead detrimental consequences in COVID-19 patients. Interleukin (IL)-18 is one of the leading cytokines in MAS which has not been studied in COVID-19.
View Article and Find Full Text PDFBackground/aim: There is a need for a scoring system for predicting ICU prognosis of patients with ANCA-associated vasculitis (AAV), but there are limited data on it in the literature. Therefore, we aimed to determine the scores that can estimate the prognosis of patients with AAV during intensive care follow up.
Materials And Methods: All adult patients admitted to the medical ICUs of 4 reference university hospitals in Turkey due to AAV activation and/or disease/treatment complications in the last 10 years were included in this study.
Purpose: In this prospective observational study, we aimed to investigate the role of the maximum compressed (MC) and uncompressed (UC) thickness of the quadriceps femoris muscle (QFMT) measured by ultrasonography (USG) in the detection of nutritional risk in intensive care patients (ICPs) with different volume status.
Methods: 55 patients were included. Right, left, and total ucQFMT and mcQFMT measurements were obtained by a standard USG device within the first 48 hours after ICU admission.
Article Synopsis
- - The study aimed to gather data on the characteristics of intensive care units (ICUs) in Turkey through a nationwide point prevalence survey conducted by the Turkish Thoracic Society.
- - Data from 67 ICUs revealed that 76.1% operated under a closed system, with 35.8% classified as Level of Care (LOC) 2 and 64.2% as LOC 3, indicating a range of critical care capacity.
- - The findings highlighted a significant need for more specialized physicians and nurses in ICUs, particularly during nighttime, although the percentage of certified ICU nurses was seen as relatively adequate, with aspirations for full certification.
Objective: Most significant side effect of colistin therapy which is used for the treatment of multi-drug resistant Gram-negative infections is nephrotoxicity. Our aim was to investigate the differences of colistin nephrotoxicity between the geriatric age group (≥65 years) and the younger age group (<65 years) in critically ill medical intensive care unit (ICU) patients.
Material And Method: The medical records of the 76 patients who were taken colistin therapy due to multi-resistant Gram-negative infections between January 2010 and June 2014 in the our medical ICU were retrospectively investigated.
Our study evaluated the differences between early and late hemodialysis (HD) initiation in the intensive care unit (ICU) according to the RIFLE (Risk, Injury, Failure, Loss, and End-stage renal failure) and AKIN (Acute Kidney Injury Network) classifications. On the assumption that early initiation of HD in critical patients according to the RIFLE and AKIN criteria decreases mortality, we retrospectively evaluated the medical records of 68 patients in our medical ICU and divided the patients into 2 groups: Those undergoing HD in no risk, risk, or injury stage according to RIFLE and in stage 0, I, or II according to AKIN were defined as early HD and those in failure stage according to RIFLE and in stage III according to AKIN were defined as late HD. The median age of the patients was 66.
View Article and Find Full Text PDFAim: Many factors affecting noninvasive ventilation (NIV) in critically ill patients have been reported in the literature, but there is no study about the effect of frailty. With this study, the frailty prevalence was evaluated with two different frailty scores among the NIV population of a medical intensive care unit (ICU). Besides, the impact of frailty on NIV success and mortality and its association with NIV application problems were evaluated.
View Article and Find Full Text PDFSaprochaete capitata (formerly known as Geotrichum capitatum and Blastoschizomyces capitatus) is a rare invasive fungal agent that may lead to mortal clinical course in patients with hematological malignancies. This agent can be colonized in skin, lungs and intestines, and it can cause major opportunistic infections. Invasive systemic infections due to S.
View Article and Find Full Text PDFArticle Synopsis
- Sepsis negatively affects capillary function and oxygen delivery, potentially worsening patient outcomes.
- Lower levels of immunoglobulin G2 do not contribute to severe flu complications, suggesting other factors may play a role in flu severity.
- New research indicates that intravenous immunoglobulin may provide brain protection during sepsis by blocking harmful immune responses such as complement activation and apoptosis. *
Article Synopsis
- - The study highlights the need for better management of healthcare costs, especially in specialized hospital settings like intensive care units (ICUs), due to limited GDP allocation for health.
- - Researchers compared the costs associated with anaesthesiology and internal medicine ICUs for 855 patients treated over a 20-month period at Gazi University Hospital.
- - Results showed significant cost differences between the two ICU types, indicating that the Social Security Institution (SSI) should adjust their reimbursement policies to better cover intensive care expenses.
Targeted temperature management, or therapeutic hypothermia, in post-resuscitation care.
Turk Kardiyol Dern Ars
March 2016