The influence of Nrf2 gene promoter methylation on gene expression and oxidative stress parameters in preeclampsia.

Background And Aims: Preeclampsia (PE) is a serious medical condition that usually causes high blood pressure and affects multiple organs. Considering the adverse effect of oxidative stress on the process of PE in pregnant women and regarding the role of the Nrf2 gene in placental oxidative pathways, this study was conducted to investigate the DNA methylation status of Nrf2 in PE and healthy pregnant women.

Materials And Methods: The present case-control study consisted of 70 PE and 70 healthy pregnant women.