Publications by authors named "Sahdev Baweja"
Toxicol Appl Pharmacol
December 2023
Article Synopsis
- Exposure to nickel can lead to serious lung diseases and the cells can remember this exposure, allowing for persistent transcriptional changes that were observed even after the nickel was gone.
- This study explores how this "transcriptional memory" from nickel exposure affects lung cells when they are later exposed to nicotine, another harmful respiratory toxicant.
- Findings indicate that cells with nickel-induced memory show increased gene activation in response to nicotine, particularly involving inflammation pathways, suggesting a higher risk of developing chronic lung diseases in those previously exposed to nickel.
