L-Arginine-induced acute pancreatitis and its associated lung injury in rats: Down-regulation of TLR-4/MAPK-p38/JNK signaling pathway via extract EGb 761.

Objectives: Acute pancreatitis (AP) is an abrupt inflammatory condition characterized by a storm of inflammatory cytokines leading to high morbidity and mortality. The current study aimed to examine the efficacy of extract EGb 761 (GBE) in the treatment of L-arginine-induced AP and its associated lung injury.

Materials And Methods: Forty rats were randomly assigned into four groups.