Differential Placental DNA Methylation of in Extremely Preterm Infants With Poorer Neurological Functioning.

Background: Understanding underlying mechanisms of neurodevelopmental impairment following preterm birth may enhance opportunities for targeted interventions. We aimed to assess whether placental DNA methylation of selected genes affected early neurological functioning in preterm infants.

Methods: We included 43 infants, with gestational age <30 weeks and/or birth weight <1,000 g and placental samples at birth.

The Early Motor Repertoire in Preterm Infancy and Cognition in Young Adulthood: Preliminary Findings.

Objective: Preterm birth poses a risk to cognition during childhood. The resulting cognitive problems may persist into young adulthood. The early motor repertoire in infancy is predictive of neurocognitive development in childhood.

Favorable parental perception of behaviour at two years' corrected age in very preterm-born children.

Problems in behavioural and emotional outcome are amongst the long-term sequelae of preterm birth. The exact prevalence and associations with perinatal risk factors are unknown. Minimal research has been performed in pre-school aged children, compared to school age.

Very Preterm Early Motor Repertoire and Neurodevelopmental Outcomes at 8 Years.

Background And Objectives: Children born very preterm (<32 weeks' gestation) have more neurodevelopmental problems compared with term-born peers. Aberrant fidgety movements (FMs) are associated with adverse motor outcomes in children born very preterm. However, associations of aberrant FMs combined with additional movements and postures to give a motor optimality score-revised (MOS-R) with school-aged cognitive and motor outcomes are unclear.

A comparison of the early motor repertoire of very preterm infants and term infants.

Objective: To obtain reference data on the early motor repertoire of very preterm infants compared with healthy term infants at three months' post-term age.

Study Design: In this observational study, using Prechtl's method on the assessment of the early motor repertoire, we compared the quality of fidgety movements and the concurrent motor optimality score - revised of infants with a gestational age <30 weeks and/or a birth weight <1000 g with healthy infants with a gestational age of 37-42 weeks.

Results: One hundred eighty very preterm and 180 healthy term infants participated.

A Parechovirus Type 3 Infection with a Presumed Intrauterine Onset: A Poor Neurodevelopmental Outcome.

Parechovirus type 3 (HPeV-3) infection is an important cause of illness in neonates. We present the first case of an infant with a HPeV-3 meningoencephalitis which presumably commenced in utero. Severe developmental delay was seen.

Fetal Brain-Sparing, Postnatal Cerebral Oxygenation, and Neurodevelopment at 4 Years of Age Following Fetal Growth Restriction.

To assess the role of fetal brain-sparing and postnatal cerebral oxygen saturation (rSO) as determinants of long-term neurodevelopmental outcome following fetal growth restriction (FGR). This was a prospective follow-up study of an FGR cohort of 41 children. Prenatally, the presence of fetal brain-sparing (cerebroplacental ratio < 1) was assessed by Doppler ultrasound.

The association between the early motor repertoire and language development in term children born after normal pregnancy.

Background: The assessment of the early motor repertoire is a widely used method for assessing the infant's neurological status.

Aim: To determine the association between the early motor repertoire and language development.

Study Design: Prospective cohort study.