Downregulation of long non-coding RNAs in patients with bipolar disorder.

The abnormal function of signaling cascades is currently a candidate in the pathophysiology of bipolar disorder (BD). One of the factors involved in activating these signals is oxidative stress. Some long non-coding RNAs (lncRNA) are involved in the oxidative stress.

Microfluidics combined with ionic gelation method for production of nanoparticles based on thiol-functionalized chitosan to adsorb Hg (II) from aqueous solutions.

This work aimed at producing nanoparticles (NPs) based on thiol-functionalized chitosan (CS) using capillary microfluidic (MF) device combined with ionic gelation method to adsorb mercury ion [Hg (II)] from aqueous solutions. In this line, CS was functionalized with epichlorohydrin/cysteaminium chloride (2.73 M ratio) followed by fabricating NPs via MF and bulk mixing (BM) methods.