A new series of bicalutamide, enzalutamide and enobosarm derivatives carrying pentafluorosulfanyl (SF) and pentafluoroethyl (CF) substituents: Improved antiproliferative agents against prostate cancer.

SAR studies on bicalutamide, enobosarm and enzalutamide analogues, functionalised with polyfluorinated groups, is presented. Among the novel bicalutamide and enobosarm derivatives synthesised, several displayed significantly improved in vitro anticancer activity, with IC values in the low micromolar range against four different prostate cancer cell lines (LNCaP, VCaP, DU-145 and 22Rv1), showing up to 48-fold increase in comparison with the parent structures. In particular, SF enobosarm analogues were found to be most potent compounds, full AR antagonists and with favourable ADME properties.