Effect of β-cyclodextrin on intra and intermolecular Michael addition of some catechol derivatives.

The oxidation reactions of catechol, dopamine and epinephrine have been studied in the absence and presence of N-methylaniline by UV-Vis. Spectrophotometry. A variety of reaction pathways (inter and intramolecular reactions) that followed by this oxidation have been observed depending on the nature of catechol derivatives.

Role of chitosan nanoparticles in the oral absorption of Gemcitabine.

Gemcitabine is a known cytotoxic agent with a wide spectrum of antitumor activity. It has been employed in therapeutic regimens for various malignancies such as the lung, ovary, breast, and bladder cancers. It also has been used in the treatment of pancreatic cancer, in combination chemotherapy of non-small cell lung cancer (NSCLC) and in leukemia.

Assessment of osteoporosis in psoriasis with and without arthritis: correlation with disease severity.

Background: The most frequent extracutaneous association with psoriasis is arthritis. Because proinflammatory cytokines are increased in psoriasis, patients with this disease may be more prone to osteoporosis than the healthy individuals.

Methods: We evaluated 50 patients with psoriasis, with or without psoriatic arthritis (PsA), for the presence and degree of osteoporosis by performing dual energy x-ray absorptiometry (DEXA) and obtaining serum osteoprotegrin (OPG) levels.