Quercetin against MCF7 and CAL51 breast cancer cell lines: apoptosis, gene expression and cytotoxicity of nano-quercetin.

To evaluate the anti breast-cancer activity, biocompatibility and toxicity of poly(d,l)-lactic--glycolic acid (PLGA)-encapsulated quercetin nanoparticles (Q-PLGA-NPs). Quercetin was nano-encapsulated by an emulsion-diffusion process, and the nanoparticles were fully characterized through Fourier transform infrared spectroscopy, x-ray diffractions, FESEM and zeta-sizer analysis. Activity against CAL51 and MCF7 cell lines were assessed by DNA fragmentation assays, fluorescence microscopy, and acridine-orange, and propidium-iodide double-stainings.

Workplace barriers encountered by employed persons with systemic sclerosis.

Background: Systemic sclerosis (SSc) is an auto-immune connective tissue disease characterized by fibrosis of skin, blood vessels, and internal organs that results in significant disability.

Objective: To identify the work barriers faced by people with systemic sclerosis (SSc) in maintaining employment.

Methods: Thirty-six people with SSc who were working more than 8 hours per week completed the Work Experience Survey, which contains lists of potential work barriers, including the ability to travel to and from work; get around at work; perform essential job functions, including physical, cognitive, and task-related activities; work with others; and manage work conditions.