Publications by authors named "Sahar Alousi"

Article Synopsis
  • Antimicrobial resistance, particularly among Gram-negative bacteria, continues to rise, making colistin an essential last-resort antibiotic despite unknown mechanisms of its resistance.
  • A study analyzing 32 carbapenem-resistant Klebsiella pneumoniae isolates found varying levels of resistance to colistin, with distinct genetic mutations and lipid A alterations contributing to this resistance.
  • The research highlights the need for alternative treatment strategies, such as combination therapies, to effectively manage colistin heteroresistance and improve treatment outcomes.
View Article and Find Full Text PDF

Detection of viable viruses in the air is critical in order to determine the level of risk associated with the airborne diffusion of viruses. Different methods have been developed for the isolation, purification, and detection of viable airborne viruses, but they require an extensive processing time and often present limitations including low physical efficiency (i.e.

View Article and Find Full Text PDF

Carbapenem-resistant (CRAB) is an important opportunistic pathogen linked to a variety of nosocomial infections and hospital outbreaks worldwide. This study aimed at investigating and characterizing a CRAB outbreak at a large tertiary hospital in Lebanon. A total of 41 isolates were collected and analyzed using pulsed-field gel electrophoresis (PFGE).

View Article and Find Full Text PDF

Klebsiella pneumoniae is a Gram-negative organism and a major public health threat. In this study, we used whole-genome sequences to characterize 32 carbapenem-resistant K. pneumoniae (CRKP) and two carbapenem-resistant K.

View Article and Find Full Text PDF

The emergence of carbapenem resistant Escherichia coli represents a serious public health concern. This study investigated the resistome, virulence, plasmids content and clonality of 27 carbapenem resistant E. coli isolated from 27 hospitalized patients at the American University of Beirut Medical Center (AUBMC) in Lebanon between 2012 and 2016.

View Article and Find Full Text PDF

Objectives: The rapid emergence of carbapenem-resistant Acinetobacter baumannii is a global health concern. A comparative genomic analysis was performed on two ST85 A. baumannii strains harboring bla and bla collected in Lebanon from Syrian Civil War victims.

View Article and Find Full Text PDF

Aim: To evaluate the effects of population influx of refugees on the prevalence of extended-spectrum β-lactamase-producing Escherichia coli in wastewater networks in Lebanon.

Materials & Methods: Pulsed-field gel electrophoresis, multilocus sequence typing and antibiotic resistance genes typing were performed.

Results: 53.

View Article and Find Full Text PDF

The escalating problem of antibiotic resistance, specifically cabarpenemase and extended-spectrum β-lacatamase (ESBL) producing K. pneumoniae strains, is directly correlated with increased patient morbidity and mortality and prolonged hospitalization and costs. In this study, a comprehensive genomic analysis encompassing the resistomics, virulence repertoire and mobile genetic elements of an NDM-1 positive ESBL-producing K.

View Article and Find Full Text PDF