Publications by authors named "Sahar Afzali Kharkouei"
Article Synopsis
- Cancer treatment involves multiple strategies like surgery, chemotherapy, radiotherapy, and innovative therapies such as hormone treatment, stem cell therapy, and immunotherapy.
- Immunotherapy is a key method that uses the body's immune system to combat cancer, helping to boost the activity of immune cells while minimizing harm to healthy cells.
- Recent research highlights the benefits of combining immunotherapies with other treatments and discusses the ongoing challenges in effectively using methods like immune checkpoint inhibitors and cancer vaccines.
Background: Endothelin-1 (ET-1) is a peptide overexpressed in gastric cancer (GC) and linked to carcinogenesis and resistance to chemotherapy. Applying microRNAs (miRNAs/miRs) to downregulate ET-1 and reverse resistance to commonly used chemotherapy drugs such as 5-fluorouracil (5-FU) is practical.
Methods: The current study sought to evaluate the miR-648 expression in GC and any plausibility of its replacement, either with or without the combination of chemo agents to downregulate ET-1 expression through interaction with its target gene.