Publications by authors named "Sahar Abd El-Razik Mosallam"
There is an urgent need for preventive and therapeutic drugs to effectively treat and prevent viral diseases from resurfacing as they emerge during the COVID-19 pandemic. This study aims to assess the antiviral effects of four natural compounds commonly used in traditional medicine to treat SARS-CoV-2 infection. A cytotoxicity, dose-dependent, and plaque reduction assay was performed on Vero CCL-81 cells to figure out their effects on the cells.
View Article and Find Full Text PDFA wide variety of health benefits have been demonstrated by medicinal plants, including potent antiviral properties. Additionally, many herbal remedies are known to reduce inflammation and boost immunity, making them an effective preventive measure against viral infections. The study aims to evaluate the perception of medicinal herbs and healthy foods during the pandemic period among Saudi patients.
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- Traditional herbal medicine, particularly Thymoquinone (TQ) from black seed and Piperine (PIP) from black pepper, shows promise in enhancing the effects of the cancer drug sorafenib (SOR) against triple-negative breast and liver cancer cells.
- The study utilized various methods like MTT assays and flow cytometry to analyze the cytotoxicity and the mechanisms of action, including effects on DNA methylation and histone acetylation.
- Results indicated that TQ and PIP combined with SOR led to increased cancer cell death and growth inhibition by downregulating certain oncogenic proteins and upregulating tumor suppressor miRNA-29c, while molecular docking studies confirmed strong interactions among these compounds.
The burden of cancer diseases is increasing every year, therefore, the demands to figure out novel drugs that can retain antitumor properties have been raised. This study aimed to investigate the anti-tumor properties of amygdalin (Amy) against Ehrlich ascites carcinoma (EAC) bearing mice and its protective properties against liver damage. Amy and the standard anticancer drug Sorafenib (Sor) were given alone or in combination to Swiss albino female mice that had been injected with EAC cells.
View Article and Find Full Text PDFIn the present study, genotoxic effect of methyl tert butyl ether MTBE was analyzed by measuring chromosomal aberrations (CAs) in bone marrow cells of rats. Rats administered MTBE orally at 800, 1600mg/kg/day in corn oil for 14 and 28 consecutive days. Control rats received injection of distilled water.
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