3D-Organoid-SwinNet: High-content profiling of 3D organoids.

Profiling of Patient-Derived organoids is necessary for drug screening and precision medicine. This step requires accurate segmentation of three-dimensional cellular structures followed by protein readouts. While fully Convolutional Neural Networks are widely used in medical image segmentation, they struggle to capture long-range dependencies necessary for accurate segmentation.

Locally injected bone marrow-derived mesenchymal stem cells reverts the histopathological changes in the tongue of carbimazole-induced hypothyroidism of male rats.

Objective: To decipher the role of locally injected bone marrow mesenchymal stem cells (BM-MSCs) in the tongue of hypothyroid rats.

Design: A total 24 male Wister rats were utilized and allocated into 3 groups (n = 8). As for the control group, rats received distilled water via oral gavage.