Publications by authors named "Sahana Shekhar"
Article Synopsis
- - The study investigates how large vesicle extrusion from neurons could spread harmful protein aggregates and trigger inflammation, both of which are linked to neurodegenerative diseases.
- - It reveals that mechanical forces, especially related to uterine occupancy, significantly enhance the production of exophers (large vesicles) from specific neurons under proteostress conditions, particularly during peak reproductive times.
- - The research suggests that factors like genetic disruption of reproductive processes and filling the uterus influence exopher production, emphasizing the role of mechanical signaling in neuron function and its potential implications for understanding neurodegenerative diseases.
Large vesicle extrusion from neurons may contribute to spreading pathogenic protein aggregates and promoting inflammatory responses, two mechanisms leading to neurodegenerative disease. Factors that regulate extrusion of large vesicles, such as exophers produced by proteostressed touch neurons, are poorly understood. Here we document that mechanical force can significantly potentiate exopher extrusion from proteostressed neurons.
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