Green synthesis of copper nanoparticles: a promising solution for drug resistance and cancer therapy challenges.

Green synthesis techniques have drawn a lot of interest lately since they are beneficial to the environment and have potential uses in a variety of industries, including biomedicine. Because of their special physicochemical characteristics, copper nanoparticles (CuNPs) have become one of the most interesting options for use in biological applications among nanomaterials. An overview of green synthesis methods for CuNPs is given in this review, along with a discussion of their applications in cancer therapeutics.

Development of an In Silico Platform (TRIPinRNA) for the Identification of Novel RNA Intramolecular Triple Helices and Their Validation Using Biophysical Techniques.

There are surprisingly few RNA intramolecular triple helices known in the human transcriptome. The structure has been most well-studied as a stability-element at the 3' end of lncRNAs such as and , but the intrigue remains whether it is indeed as rare as it is understood to be or just waiting for a closer look from a new vantage point. TRIPinRNA, our Python-based in silico platform, allows for a comprehensive sequence-pattern search for potential triplex formation in the human transcriptome─noncoding as well as coding.

Pertinence of Five Different Regression Equations of Mixed Dentition Analysis in West Godavari District Children: A Comparative Study.

Aim And Background: The orthodontic diagnosis and treatment planning are the fundamental goals during the mixed dentition period. Numerous methods have been proposed to date. The study was designed to determine the mesiodistal (MD) widths of the lower permanent canines and premolars from Tanaka and Johnston, regression equation (RE) proposed for north Indian population (RE-NIP), Bernabé and Flores-Mir C, Moyers', and Ling and Wong mixed dentition analysis (MDA) and to determine the correlation coefficients for the Eluru population.

Investigation of Host-Guest Inclusion Complex of Mephenesin with α-Cyclodextrin for Innovative Application in Biological System.

The goal of this study was to use coevaporation to look into how polyether compounds like mephenesin (MEP) can be encapsulated into the host molecule α-cyclodextrin's nanohydrophobic cage. Fourier transform infrared spectroscopy (FT-IR) investigations, powder X-ray diffraction (PXRD), and H NMR were among the spectroscopic techniques used to describe the inclusion complex. Additionally, Job's plot has been utilized to illustrate how MEP is encapsulated with α-cyclodextrin (α-CD) at a 1:1 molar ratio.

Impact of Comprehensive Dental Health Program on the Oral Health-related Quality of Life among Socially Handicapped Children.

Aim: Socially handicapped children face a number of challenges including limited access to basic health including oral healthcare. The aim of this study is to determine the oral health status and treatment needs of socially handicapped children and to assess the effectiveness of the Comprehensive Dental Health Program (CDHP) on their oral health-related quality of life (OHRQoL).

Materials And Methods: A total of 97 children in the age-group of 7-14 years were enrolled in the study.

Facile synthesis of iron nanoparticles from Camellia Sinensis leaves catalysed for biodiesel synthesis from Azolla filiculoides.

Recent years have seen an increase in research on biodiesel, an environmentally benign and renewable fuel alternative for traditional fossil fuels. Biodiesel might become more cost-effective and competitive with diesel if a solid heterogeneous catalyst is used in its production. One way to make biodiesel more affordable and competitive with diesel is to employ a solid heterogeneous catalyst in its manufacturing.

A Pyrene Coupled Azaine-linkage Chromo-fluorogenic Probe for Specific Detection of Sarin Gas Stimulant, Diethylchlorophosphate.

Owing to the extreme toxicity and easy synthesis protocol of G-series nerve agents, developing an efficient sensor for selective detection is necessary. Although various traditional methods are utilized to identify these nerve agents, chromo-fluorogenic probes have gained attractive attention from the scientific communities. In the present contribution, we have introduced a new symmetrical aza-substituted chromo-fluorogenic sensor, BPH, for specific detection of sarin gas, one of the fatal G-series nerve agents surrogate, diethylchlorophosphate (DCP).

The phenomenological approach in dentistry - a narrative review.

Purpose: Phenomenology is a branch of philosophy that focuses on human lived experience. Illness including dental diseases can affect this living experience. Within the dental literature, there is very little reported on the use of phenomenology compared to other healthcare sciences.

Landscape of pharmacogenetic variants associated with non-insulin antidiabetic drugs in the Indian population.

Introduction: Genetic variants contribute to differential responses to non-insulin antidiabetic drugs (NIADs), and consequently to variable plasma glucose control. Optimal control of plasma glucose is paramount to minimizing type 2 diabetes-related long-term complications. India's distinct genetic architecture and its exploding burden of type 2 diabetes warrants a population-specific survey of NIAD-associated pharmacogenetic (PGx) variants.

The genomic landscape of variation in the Indian population.

The gene is highly polymorphic, causing large interindividual variability in the metabolism of several clinically important drugs. The authors investigated the diversity and distribution of alleles in Indians using whole genome sequences (N = 1518). Functional consequences were assessed using pathogenicity scores and molecular dynamics simulations.

A recent update on development, synthesis methods, properties and application of natural products derived carbon dots.

Natural resources are practically infinitely abundant in nature, which stimulates scientists to create new materials with inventive uses and minimal environmental impact. Due to the various benefits of natural carbon dots (NCDs) from them has received a lot of attention recently. Natural products-derived carbon dots have recently emerged as a highly promising class of nanomaterials, showcasing exceptional properties and eco-friendly nature, which make them appealing for diverse applications in various fields such as biomedical, environmental sensing and monitoring, energy storage and conversion, optoelectronics and photonics, agriculture, quantum computing, nanomedicine and cancer therapy.

Improved disease diagnosis system for COVID-19 with data refactoring and handling methods.

The novel coronavirus illness (COVID-19) outbreak, which began in a seafood market in Wuhan, Hubei Province, China, in mid-December 2019, has spread to almost all countries, territories, and places throughout the world. And since the fault in diagnosis of a disease causes a psychological impact, this was very much visible in the spread of COVID-19. This research aims to address this issue by providing a better solution for diagnosis of the COVID-19 disease.

Medical image registration utilizing tissue P systems.

The tissue P system (TPS) possesses intrinsic attributes of parallel execution in comprehensive data and instruction space, which provides fast convergence during the transition from local to global optima. Method- In this study, we have proposed and built a TPSysIR framework using the TPS for image registration that optimizes upon the mutual information (MI) similarity metric to find a global solution. Result- The model was tested on single- and multimodal brain MRI scans and other prominent optimization-based image registration techniques.

Pharmacogenomic landscape of Indian population using whole genomes.

Ethnic differences in pharmacogenomic (PGx) variants have been well documented in literature and could significantly impact variability in response and adverse events to therapeutics. India is a large country with diverse ethnic populations of distinct genetic architecture. India's national genome sequencing initiative (IndiGen) provides a unique opportunity to explore the landscape of PGx variants using population-scale whole genome sequences.

Partially defatted tomato seed flour as a fat replacer: effect on physicochemical and sensory characteristics of millet-based cookies.

Abstract: Fat is an essential component for cookies structure and sensory attributes, but there is a necessity to replace or mimic fat in order to prevent lifestyle diseases. Hence, this study investigated the effect of industrial by-product, i.e.

Allergens in Hand, Foot, and Hand-Foot Eczema: An Intercomparison by Patch Testing.

Background: Hand eczema (HE), foot eczema (FE), and hand-foot eczema (HFE) manifest on exposure to various agents in day-to-day life or in occupations or both.

Objectives: The objectives of this study were to identify pattern of allergens causing HE, FE, and HFE and to identify multiple and concurrent contact allergies.

Materials And Methods: A study was conducted from October 2013 to August 2015 which included 190 patients.

Pharmacogenomic landscape of COVID-19 therapies from Indian population genomes.

Numerous drugs are being widely prescribed for COVID-19 treatment without any direct evidence for the drug safety/efficacy in patients across diverse ethnic populations. We analyzed whole genomes of 1029 Indian individuals (IndiGen) to understand the extent of drug-gene (pharmacogenetic), drug-drug and drug-drug-gene interactions associated with COVID-19 therapy in the Indian population. We identified 30 clinically significant pharmacogenetic variants and 73 predicted deleterious pharmacogenetic variants.

The assessment of Golden proportion in primary dentition.

Background: Golden proportion is a constant ratio that exists in nature, responsible for the esthetic appeal of parts in the human body. The study was aimed to assess the existence of golden proportion in primary dentition by evaluating the average width and height ratio of maxillary anterior teeth.

Materials And Methods: A total of 200 children comprising equal number of males and females aged 3-7 years with all deciduous teeth present were randomly selected.

Benzothiazole integrated into a cryptand for ESIPT-based selective chemosensor for Zn ions.

A novel benzothiazole-based cryptand was designed and synthesized, and it exhibited high fluorescence intensity in the presence of Zn ions based on the metal chelation inhibition of the excited state intramolecular proton transfer (ESIPT) process. The structure of the cryptand was confirmed by NMR, mass spectroscopy and X-ray crystallography. Importantly, this probe showed high selectivity over other biologically relevant metal ions and anions and a detection limit of 0.

Profile of HIV serodiscordant couples in a tertiary care center.

Background: Globally, 36.7 million people are infected with Human Immunodeficiency Virus (HIV). Of these 36.

Estimation of Salivary Glucose, Calcium, Phosphorus, Alkaline Phosphatase, and Immunoglobulin A among Diabetic and Nondiabetic Children: A Case-Control Study.

Introduction: Saliva is vital for oral health and helps to maintain oral homeostasis. It may show qualitative and quantitative variations owing to any changes in the systemic health. Diabetes mellitus (DM) is a metabolic disease and the individuals may be at higher risk for oral health problems.

Prevalence of Early Childhood Caries in Children of West Godavari District, Andhra Pradesh, South India: An Epidemiological Study.

Aim: To determine the prevalence of early childhood caries (ECC) and its risk factors in children of West Godavari district, Andhra Pradesh.

Study Design: A sample of 1,897 children between 24 and 71 months of age based on stratified cluster random sampling were clinically examined for dental caries using mouth mirror under day light. The parents/caregivers of each child were interviewed with a structured questionnaire.

Effectiveness of chemomechanical caries removal agents Papacarie(®) and Carie-Care™ in primary molars: An in vitro study.

Aims And Objectives: The chemomechanical caries removal system is made presently available containing a natural proteolytic enzyme for ease in the excavation of infected dentin. The aim of the study was to evaluate the efficacy and efficiency of caries removal using Papacarie(®) and Carie-Care™.

Materials And Methods: A total of 30 extracted deciduous molars with proximal caries were collected, and each tooth was sectioned mesiodistally in the center of the carious lesion so that the two halves (buccal and lingual or palatal) have similar carious lesions, thus 30 teeth yielded 60 specimens.

A Comparison of the Effectiveness of Oral Midazolam -N2O Versus Oral Ketamine - N2O in Pediatric Patients-An in-Vivo Study.

Introduction: Most children are casual and moderately agreeable in the dental treatment environment, however some of them show practices that upset the professional and make the protected conveyance of worthy treatment extremely troublesome. For such cases dental practitioner utilizes behavior management techniques. At the point when behavioral administration procedures come up short, some type of pharmacologic sedation or anesthesia may be an important and vital option.