Short Intracortical Inhibition During Voluntary Movement Reveals Persistent Impairment Post-stroke.

Short intracortical inhibition (SICI) is a GABA-mediated phenomenon, argued to mediate selective muscle activation during coordinated motor activity. Markedly reduced SICI has been observed in the acute period following stroke and, based on findings in animal models, it has been posited this disinhibitory phenomenon may facilitate neural plasticity and contribute to early motor recovery. However, it remains unresolved whether SICI normalizes over time, as part of the natural course of stroke recovery.