Prenatal diagnosis of the rarest conjoint twin "diprosopus tetrophthalmus" during anomaly scan: A case report.

Twin pregnancy is considered high-risk pregnancy because of its various effects on maternal and fetal physiology. Twin pregnancy can be dizygotic or monozygotic, the latter being less common. Depending upon the period of separation of an embryo, monozygotic twins can share amniotic cavity and placenta with the monochorionic monoamniotic form being the least common type.

Variational Autoencoders for Network Lifetime Enhancement in Wireless Sensors.

Wireless sensor networks (WSNs) are structured for monitoring an area with distributed sensors and built-in batteries. However, most of their battery energy is consumed during the data transmission process. In recent years, several methodologies, like routing optimization, topology control, and sleep scheduling algorithms, have been introduced to improve the energy efficiency of WSNs.

Mechanism and application of bacterial exopolysaccharides: An advanced approach for sustainable heavy metal abolition from soil.

The escalation of heavy metal pollutants in soils and effluents, driven by industrialization and human activities, poses significant environmental and health risks. Conventional remediation methods are often costly and ineffective, prompting a shift towards sustainable alternatives such as biological treatments. Natural biosorbents, including microbial cells and their byproducts, have emerged as promising solutions.

Opioids and Cancer: Current Understanding and Clinical Considerations.

Pain is one of the most common symptoms in patients with cancer. Pain not only negatively affects the quality of life of patients with cancer, but it has also been associated with reduced survival. Pain management is therefore a critical component of cancer care.

Redox Regulation of Phosphatase and Tensin Homolog by Bicarbonate and Hydrogen Peroxide: Implication of Peroxymonocarbonate in Cell Signaling.

Phosphatase and tensin homolog (PTEN) is a negative regulator of the phosphoinositide 3-kinases/protein kinase B (PI3K/AKT) signaling pathway. Notably, its active site contains a cysteine residue that is susceptible to oxidation by hydrogen peroxide (HO). This oxidation inhibits the phosphatase function of PTEN, critically contributing to the activation of the PI3K/AKT pathway.

Sulforaphane Inhibits IL-1β-Induced IL-6 by Suppressing ROS Production, AP-1, and STAT3 in Colorectal Cancer HT-29 Cells.

Colorectal cancer (CRC) stands as a major cause of cancer-related mortality globally, accounting for approximately 881,000 deaths each year. Traditional approaches such as chemotherapy and surgery have been the primary treatment modalities, yet the outcomes for patients with metastatic CRC are often unsatisfactory. Recent research has focused on targeting the pathways involved in oxidative stress, inflammation, and metastasis to enhance the survival of CRC patients.

Prediction of Postoperative Major Complications in Pancreaticoduodenectomy -a Prospective Comparative Analysis of Braga and WHipple-ABACUS Scores.

Background Major complications following pancreaticoduodenectomy have a severely deleterious effect on postoperative course, rather than just occurrence of pancreatic fistula. Surgical risk stratification with Braga and WHipple-ABACUS have been proposed and validated. Objective The study aimed at comparing the Braga and WHipple-ABACUS scores for prediction of major complications following pancreaticoduodenectomies.

Large Cell Neuroendocrine Carcinoma of Gallbladder: A Case Report.

Unlabelled: Large cell neuroendocrine carcinoma of the gallbladder is an extremely rare tumour with aggressive behaviour and a bad prognosis. Here, we report a case of a 65-year-old lady suspected of carcinoma of the gallbladder and underwent extended cholecystectomy. The histopathology report revealed neuroendocrine carcinoma of a large cell type of gall bladder infiltrating the liver and three periportal and pericholedochal lymph nodes.

Redox Regulation of PTEN by Reactive Oxygen Species: Its Role in Physiological Processes.

Phosphatase and tensin homolog (PTEN) is a tumor suppressor due to its ability to regulate cell survival, growth, and proliferation by downregulating the PI3K/AKT signaling pathway. In addition, PTEN plays an essential role in other physiological events associated with cell growth demands, such as ischemia-reperfusion, nerve injury, and immune responsiveness. Therefore, recently, PTEN inhibition has emerged as a potential therapeutic intervention in these situations.

Granular Hemostatic Composite of Alginate, Calcium, and Zinc for Rapid and Effective Management of Post-Traumatic Hemorrhage.

Post-traumatic hemorrhage, which can result from accidents or battlefield injuries, is a significant global concern due to the high prehospital mortality rate. Substantial efforts have been made to develop hemostatic agents that can effectively reduce hemorrhage in the immediate aftermath of a traumatic event. The present study investigated the potential efficacy of Ca and Zn supplemented sodium alginate-based dry hemostatic particles (SA-CZ DHP) to manage excessive blood loss or post-traumatic hemorrhage.

Bio-mediated detoxification of heavy metal contaminated soil and phytotoxicity reduction using novel strain of SMA3.

Heavy metals pose a serious environmental threat on a global scale due to their toxicity towards livings. Therefore, removing harmful metals from the environment has become more challenging in recent years. The objective of this study is to isolate, examine, and characterize naturally existing bacteria that possess the ability to mitigate and detoxify heavy metals such as cadmium, mercury, and lead.

HOMLC-Hyperparameter Optimization for Multi-Label Classification of Intrusion Detection Data for Internet of Things Network.

The comparison of low-rank-based learning models for multi-label categorization of attacks for intrusion detection datasets is presented in this work. In particular, we investigate the performance of three low-rank-based machine learning (LR-SVM) and deep learning models (LR-CNN), (LR-CNN-MLP) for classifying intrusion detection data: Low Rank Representation (LRR) and Non-negative Low Rank Representation (NLR). We also look into how these models' performance is affected by hyperparameter tweaking by using Guassian Bayes Optimization.

Reactive Oxygen Species and Infection: A Comprehensive Review of Their Roles in Gastric Cancer Development.

Gastric cancer (GC) is the fifth most common cancer worldwide and makes up a significant component of the global cancer burden. () is the most influential risk factor for GC, with the International Agency for Research on Cancer classifying it as a Class I carcinogen for GC. has been shown to persist in stomach acid for decades, causing damage to the stomach's mucosal lining, altering gastric hormone release patterns, and potentially altering gastric function.

Elicitation of E-waste (acrylonitrile-butadiene styrene) enriched soil bioremediation and detoxification using Priestia aryabhattai MGP1.

Given the rise in both usage and disposal of dangerous electronics, there is a catastrophic rise in assemblage of electronic waste (e-waste). E-waste including various plastic resins are among the most frequently discarded materials in electronic gadgets. In current digital era, managing e-waste has become universal concern.

Detection of Android Malware in the Internet of Things through the K-Nearest Neighbor Algorithm.

Predicting attacks in Android malware devices using machine learning for recommender systems-based IoT can be a challenging task. However, it is possible to use various machine-learning techniques to achieve this goal. An internet-based framework is used to predict and recommend Android malware on IoT devices.

Secure Data Aggregation Based on End-to-End Homomorphic Encryption in IoT-Based Wireless Sensor Networks.

By definition, the aggregating methodology ensures that transmitted data remain visible in clear text in the aggregated units or nodes. Data transmission without encryption is vulnerable to security issues such as data confidentiality, integrity, authentication and attacks by adversaries. On the other hand, encryption at each hop requires extra computation for decrypting, aggregating, and then re-encrypting the data, which results in increased complexity, not only in terms of computation but also due to the required sharing of keys.

Attribute-Based Encryption Schemes for Next Generation Wireless IoT Networks: A Comprehensive Survey.

Most data nowadays are stored in the cloud; therefore, cloud computing and its extension-fog computing-are the most in-demand services at the present time. Cloud and fog computing platforms are largely used by Internet of Things (IoT) applications where various mobile devices, end users, PCs, and smart objects are connected to each other via the internet. IoT applications are common in several application areas, such as healthcare, smart cities, industries, logistics, agriculture, and many more.

A calcium and zinc composite alginate hydrogel for pre-hospital hemostasis and wound care.

We developed, characterized, and examined the hemostatic potential of sodium alginate-based Ca and Zn composite hydrogel (SA-CZ). SA-CZ hydrogel showed substantial in-vitro efficacy, as observed by the significant reduction in coagulation time with better blood coagulation index (BCI) and no evident hemolysis in human blood. SA-CZ significantly reduced bleeding time (≈60 %) and mean blood loss (≈65 %) in the tail bleeding and liver incision in the mice hemorrhage model (p ≤ 0.

Identification of the molecular mechanism of insulin-like growth factor-1 (IGF-1): a promising therapeutic target for neurodegenerative diseases associated with metabolic syndrome.

Neurodegenerative disorders are accompanied by neuronal degeneration and glial dysfunction, resulting in cognitive, psychomotor, and behavioral impairment. Multiple factors including genetic, environmental, metabolic, and oxidant overload contribute to disease progression. Recent evidences suggest that metabolic syndrome is linked to various neurodegenerative diseases.

Bile acids and microbes in metabolic disease.

Bile acids (BAs) serve as physiological detergents that enable the intestinal absorption and transportation of nutrients, lipids and vitamins. BAs are primarily produced by humans to catabolize cholesterol and play crucial roles in gut metabolism, microbiota habitat regulation and cell signaling. BA-activated nuclear receptors regulate the enterohepatic circulation of BAs which play a role in energy, lipid, glucose, and drug metabolism.

Mitochondrial uncoupler DNP induces coexistence of dual-state hyper-energy metabolism leading to tumor growth advantage in human glioma xenografts.

Introduction: Cancer bioenergetics is an essential hallmark of neoplastic transformation. Warburg postulated that mitochondrial OXPHOS is impaired in cancer cells, leading to aerobic glycolysis as the primary metabolic pathway. However, mitochondrial function is altered but not entirely compromised in most malignancies, and that mitochondrial uncoupling is known to increase the carcinogenic potential and modifies treatment response by altering metabolic reprogramming.

(-)-Epigallocatechin-3-Gallate Prevents IL-1β-Induced uPAR Expression and Invasiveness via the Suppression of NF-κB and AP-1 in Human Bladder Cancer Cells.

(-)-Epigallocatechin-3-O-gallate (EGCG), a primary green tea polyphenol, has powerful iron scavengers, belongs to the family of flavonoids with antioxidant properties, and can be used to prevent cancer. Urokinase-type plasminogen activator receptors (uPARs) are glycosylphosphatidylinositol (GPI)-anchored cell membrane receptors that have crucial roles in cell invasion and metastasis of several cancers including bladder cancer. The mechanism of action of EGCG on uPAR expression has not been reported clearly yet.

Sulforaphane Regulates eNOS Activation and NO Production via Src-Mediated PI3K/Akt Signaling in Human Endothelial EA.hy926 Cells.

Sulforaphane (SFN) is a naturally occurring isothiocyanate that is abundant in many cruciferous vegetables, such as broccoli and cauliflower, and it has been observed to exert numerous biological activities. In the present study, we investigate the effect of SFN on eNOS, a key regulatory enzyme of vascular homeostasis and underlying intracellular pathways, in human endothelial EA.hy926 cells.

A review on biosurfactant producing bacteria for remediation of petroleum contaminated soils.

The discharge of potentially toxic petroleum hydrocarbons into the environment has been a matter of concern, as these organic pollutants accumulate in many ecosystems due to their hydrophobicity and low bioavailability. Petroleum hydrocarbons are neurotoxic and carcinogenic organic pollutants, extremely harmful to human and environmental health. Traditional treatment methods for removing hydrocarbons from polluted areas, including various mechanical and chemical strategies, are ineffective and costly.