Publications by authors named "Sahın E"

Unlabelled: This study aims to evaluate the clinical course of critical pertussis illness to the pediatric intensive care unit in Istanbul. The study was conducted as a multicenter, retrospective study between January 1, 2023, and December 31, 2023. Cases with positive polymerase chain reaction testing for Bordetella pertussis of nasopharyngeal swab samples within the first 24 h of pediatric intensive care unit admission were recorded.

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Conventional Fourier domain Optical Coherence Tomography (FD-OCT) systems depend on resampling into a wavenumber () domain to extract the depth profile. This either necessitates additional hardware resources or amplifies the existing computational complexity. Moreover, the OCT images also suffer from speckle noise, due to systemic reliance on low-coherence interferometry.

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The main purpose of this study is to prepare a melamine aniline formaldehyde foam, an MAF copolymer, with lower water sensitivity and non-flammability properties obtained by the condensation reaction of melamine, aniline, and formaldehyde. In addition, the preparation of MAFF composites with organoclay reinforcement was determined as a secondary target in order to obtain better mechanical strength, heat, and sound insulation properties. For the synthesis of foams, the microwave irradiation technique, which offers advantages such as faster reactions, high yields and purities, and reduced curing times, was used together with the heating technique and the effect of organoclay content on the structural and textural properties of foams and both heat insulation and mechanical stability was investigated.

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: The ketogenic diet (KD) is a dietary model that can impact metabolic health and microbiota and has been widely discussed in recent years. This study aimed to evaluate the effects of a 6-week KD on biochemical parameters, gut microbiota, and fecal short-chain fatty acids (SCFAs) in women with overweight/obesity. : Overall, 15 women aged 26-46 years were included in this study.

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With increasing interest in plant-based compounds that can enhance sleep quality without the side effects of caffeine, Alpinia galanga (AG) has emerged as a promising herbal supplement for improving mental alertness. This study assessed the impact of water-soluble AG extract on sleep quality; the activity of GABAergic, glutamatergic, and serotonergic receptors; and concentrations of dopamine and serotonin in the brains of mice. The study employed two experimental models using BALB/c mice to examine the impact of pentobarbital-induced sleep and caffeine-induced insomnia.

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  • Hepatocellular carcinoma (HCC) is a major global health issue often diagnosed late, making early detection critical yet difficult.
  • This study utilizes deep learning with the You Only Look Once (YOLO) architecture to improve HCC detection in CT images, using a dataset of 1290 images from 122 patients.
  • The YOLO model achieved impressive diagnostic results, with a precision of 0.97216, recall of 0.919, and overall accuracy of 95.35%, indicating its potential to enhance early diagnosis and patient outcomes in clinical settings.
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Introduction: Medical education typically focuses on the dyadic interaction between patient and physician. However, there is another significant presence in the room that can also impact the patient's health outcomes: caregivers. This topic has been relatively underexplored until now, and there is insufficient information available regarding situations in different cultures.

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Schwannomas commonly occur in the head and neck region but are rarely seen in the gastrointestinal tract; the stomach and small intestine are the most commonly involved sites. These tumors are usually misdiagnosed as gastrointestinal stromal tumors (GISTs) before histopathological confirmation due to radiological similarity. GI schwannomas show positivity for S100 protein and vimentin but are negative for CD 117 and CD 34, which helps in differentiating the tumor from GISTs.

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Background: The anti-JCV antibody index is widely used to monitor multiple sclerosis (MS) patients receiving natalizumab, as seroconversion is linked to an increased risk of progressive multifocal leukoencephalopathy. This study aimed to evaluate the prevalence and risk factors of anti-JCV antibody seroconversion in patients treated with natalizumab.

Methods: We included MS patients exposed to natalizumab treatment for at least one year, with a negative anti-JCV antibody index at baseline, and a minimum of two anti-JCV antibody assessments more than six months apart.

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This work describes one-step syntheses of various stereogenic-at-boron fluorochromes (BOSPYR) multicomponent reactions involving readily accessible boronic acids, salicylaldehydes, and 2-formylpyrrole hydrazones. The dyes absorb and emit in the visible region of the electromagnetic radiation, and are characterized by large Stokes shifts (2850-4930 cm) with weak fluorescence emissions (: 1.5-9.

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Objective: In patients with Restless Legs Syndrome (RLS), neuropsychiatric comorbidities like anxiety, depression, and somatization are common, yet the precise connection between somatization and RLS severity remains unclear. This study aims to elucidate the influence of neuropsychiatric comorbidities on RLS severity, focusing particularly on the role of somatization.

Methods: This cross-sectional analytical study was conducted at a tertiary hospital.

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Background: The demand for labia minora reduction surgery has increased due to aesthetic preferences and discomfort caused by labial hypertrophy. This study aims to share experiences with labial reconstruction using clitoral hood flaps in patients who underwent aggressive trim labiaplasty.

Methods: Twenty-eight patients who had previously undergone only labiaplasty surgery were included in this study.

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  • The study assesses how effective and safe intravitreal chlorhexidine (CHX) is in sterilizing the vitreous cavity for bacterial endophthalmitis.
  • In vitro, CHX concentrations above 6.25 µg/mL effectively killed bacteria, and doses below 200 µg/mL did not harm retinal cells.
  • Animal testing showed that CHX concentrations of 20-100 µg/mL could sterilize the vitreous without causing harmful effects, suggesting potential for clinical application.*
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  • The study compared the effectiveness and safety of FOLFIRI combined with bevacizumab versus FOLFIRI combined with aflibercept in patients with RAS-mutant metastatic colon cancer who had previously received treatment.
  • Results showed that patients receiving FOLFIRI with bevacizumab had a median overall survival (OS) of 14.1 months and progression-free survival (PFS) of 7.7 months, which were significantly better than those treated with aflibercept (OS: 11.2 months, PFS: 5.7 months).
  • Additionally, the bevacizumab group experienced fewer severe side effects (50.9% in aflibercept group vs 25.
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  • The study explores the use of biobased cellulosic materials and bioinspired 4D-printing for creating adaptive shading systems in building facades to reduce carbon emissions and energy consumption.
  • The key focuses include assessing the movement of 4D-printed bilayers in response to temperature and humidity, testing their effectiveness in varying weather conditions over a year, and implementing these systems in actual building facades for practical applications.
  • Overall, the research highlights the potential of these innovative materials and techniques to provide eco-friendly, efficient solutions for managing indoor climates and addressing climate change.
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  • The study investigates the role of specific SNPs in the CDH1 gene and their association with gastric cancer risk, focusing on three SNPs: rs16260, rs13689, and rs9929218.
  • Among the SNPs, only rs13689 showed a significant association with gastric cancer, as patients had a much higher frequency of the T allele compared to healthy controls, indicating a fourfold increased risk.
  • The findings suggest that the T allele of rs13689 may significantly contribute to susceptibility to gastric cancer, while the other two SNPs may have implications for smokers.
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Background: In recent years, limited studies have evaluated the development of cultural awareness, sensitivity, skills, communication and competence among nursing students using different models and curricula.

Objectives: This study aimed to evaluate the effectiveness of a new internationally developed curriculum for transcultural nursing education.

Methods: This mixed methods study was conducted on nursing students (n = 83) who attended a transcultural nursing course from 2021 to 2022 during the fall semester.

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  • This study focused on how witnessing domestic violence affects university students' health behaviors, particularly in terms of risky behaviors like substance abuse and alcohol consumption.
  • A total of 2,509 university students were analyzed using path analysis to understand the link between their backgrounds and these risky behaviors.
  • The findings revealed that witnessing domestic violence led to increased substance abuse and alcohol use overall, and specifically heightened partner violence among female students, highlighting the significant impact of such experiences on health.
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Objectives: To evaluate the possible impact of RAST on optimal antimicrobial therapy via de-escalation or escalation, and to determine the reduction in antibiotic susceptibility reporting time with RAST.

Methods: In this single-center, prospective descriptive study, RAST was performed on clinical blood cultures containing E. coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii isolates.

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Surgical trauma can induce systemic inflammation. The selected anesthesia method may modulate the inflammatory response and surgical results in the inflammatory process that occurs during surgical trauma. In this retrospective study, we aimed to compare the anti-inflammatory effects of general anesthesia and peripheral nerve block (infraclavicular block).

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Unlabelled: Studying the diversity of viruses found in uncultivated fungi, including those forming mycorrhizal relationships, is essential. It's equally important to explore viral communities in fungi that cause plant diseases or are economically significant. This dual approach helps us grasp the full scope of mycovirus diversity and evolution.

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: The role of the gut microbiome in the development and progression of many diseases has received increased attention in recent years. Boron, a trace mineral found in dietary sources, has attracted interest due to its unique electron depletion and coordination characteristics in chemistry, as well as its potential role in modulating the gut microbiota. This study investigates the effects of inorganic boron derivatives on the gut microbiota of mice.

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Digital and mechatronic methods, paired with artificial intelligence and machine learning, are transformative technologies in behavioral science and biology. The central element of the most important pollinator species-honey bees-is the colony's queen. Because honey bee self-regulation is complex and studying queens in their natural colony context is difficult, the behavioral strategies of these organisms have not been widely studied.

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: Magnesium alloys degrade rapidly in salt solutions, which limits their use without passivating treatments. AZ31 alloy is particularly promising for implant applications owing to its biodegradability and mechanical properties, necessitating effective corrosion-resistant coatings. : In this study, a self-passivating reactive coating was designed and evaluated for AZ31 magnesium alloy plates using β-tricalcium phosphate (TCP) to enhance corrosion resistance and biocompatibility.

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